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New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes.

Publication ,  Journal Article
Urtreger, AJ; Diament, MJ; Ranuncolo, SM; Del C Vidal, M; Puricelli, LI; Klein, SM; De Kier Joffe, ED
Published in: Int J Oncol
March 2001
Published version (DOI) Link to item

LP07 is a new cell line derived from P07 lung tumor, spontaneously arisen in a BALB/c mouse. LP07 is composed of heterogeneous epithelioid polyhedric cells that proliferate at a slow rate, have low plating efficiency and are unable to grow in soft agar. Only some LP07 cells expressed cytokeratins while most of them were positive for vimentin. Ultrastructure studies showed that LP07 cells established rudimentary intercellular unions, formed glandular-like conducts and presented conspicuous secretory granules, suggesting an epithelial-glandular origin, with neuroendocrine components. Upon injection LP07 cells formed poorly differentiated non-invasive adenocarcinomas, and tumor bearing mice developed leukocytosis, hypercalcemia and cachexia. This tumor cell line constitutes a useful tool to study lung tumor biology and paraneoplastic syndromes.

Duke Scholars

Stephen Matthew Klein
Author Stephen Matthew Klein Anesthesiology, Ambulatory

Published In

Int J Oncol

DOI

10.3892/ijo.18.3.639

ISSN

1019-6439

Publication Date

March 2001

Volume

18

Issue

3

Start / End Page

639 / 647

Location

Greece

Related Subject Headings

  • Urokinase-Type Plasminogen Activator
  • Tumor Cells, Cultured
  • Paraneoplastic Syndromes
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Microscopy, Electron
  • Mice, Inbred BALB C
  • Mice
  • Lung Neoplasms
  • Immunoenzyme Techniques
 

Citation

APA
Chicago
ICMJE
MLA
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Urtreger, A. J., Diament, M. J., Ranuncolo, S. M., Del C Vidal, M., Puricelli, L. I., Klein, S. M., & De Kier Joffe, E. D. (2001). New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. Int J Oncol, 18(3), 639–647. https://doi.org/10.3892/ijo.18.3.639
Urtreger, A. J., M. J. Diament, S. M. Ranuncolo, M. Del C Vidal, L. I. Puricelli, S. M. Klein, and E. D. De Kier Joffe. “New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes.” Int J Oncol 18, no. 3 (March 2001): 639–47. https://doi.org/10.3892/ijo.18.3.639.
Urtreger AJ, Diament MJ, Ranuncolo SM, Del C Vidal M, Puricelli LI, Klein SM, et al. New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. Int J Oncol. 2001 Mar;18(3):639–47.
Urtreger, A. J., et al. “New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes.” Int J Oncol, vol. 18, no. 3, Mar. 2001, pp. 639–47. Pubmed, doi:10.3892/ijo.18.3.639.
Urtreger AJ, Diament MJ, Ranuncolo SM, Del C Vidal M, Puricelli LI, Klein SM, De Kier Joffe ED. New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. Int J Oncol. 2001 Mar;18(3):639–647.

Published In

Int J Oncol

DOI

10.3892/ijo.18.3.639

ISSN

1019-6439

Publication Date

March 2001

Volume

18

Issue

3

Start / End Page

639 / 647

Location

Greece

Related Subject Headings

  • Urokinase-Type Plasminogen Activator
  • Tumor Cells, Cultured
  • Paraneoplastic Syndromes
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Microscopy, Electron
  • Mice, Inbred BALB C
  • Mice
  • Lung Neoplasms
  • Immunoenzyme Techniques