Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.

Publication ,  Journal Article
Sawcer, SJ; Maranian, M; Singlehurst, S; Yeo, T; Compston, A; Daly, MJ; De Jager, PL; Gabriel, S; Hafler, DA; Ivinson, AJ; Lander, ES ...
Published in: Hum Mol Genet
September 1, 2004

To explore the potential value of recently developed high-density linkage mapping methods in the analysis of complex disease we have regenotyped five nuclear families first studied in the 1996 UK multiple sclerosis linkage genome screen, using Applied Biosystems high-density microsatellite linkage mapping set, the Illumina BeadArray linkage mapping panel (version 3) and the Affymetrix GeneChip Human Mapping 10K array. We found that genotyping success, information extraction and genotyping accuracy were improved with all systems. These improvements were particularly marked with the SNP-based methods (Illumina and Affymetrix), with little difference between these. The extent of additional information extracted is considerable, indicating that reanalysis of existing multiplex families using these newer systems would substantially increase power.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Hum Mol Genet

DOI

ISSN

0964-6906

Publication Date

September 1, 2004

Volume

13

Issue

17

Start / End Page

1943 / 1949

Location

England

Related Subject Headings

  • United Kingdom
  • Polymorphism, Single Nucleotide
  • Multiple Sclerosis
  • Microsatellite Repeats
  • Humans
  • Genotype
  • Genetics & Heredity
  • Genetic Markers
  • Evaluation Studies as Topic
  • Chromosome Mapping
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sawcer, S. J., Maranian, M., Singlehurst, S., Yeo, T., Compston, A., Daly, M. J., … Haines, J. L. (2004). Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Hum Mol Genet, 13(17), 1943–1949. https://doi.org/10.1093/hmg/ddh202
Sawcer, Stephen J., Mel Maranian, Sara Singlehurst, TaiWai Yeo, Alastair Compston, Mark J. Daly, Philip L. De Jager, et al. “Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.Hum Mol Genet 13, no. 17 (September 1, 2004): 1943–49. https://doi.org/10.1093/hmg/ddh202.
Sawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, et al. Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Hum Mol Genet. 2004 Sep 1;13(17):1943–9.
Sawcer, Stephen J., et al. “Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.Hum Mol Genet, vol. 13, no. 17, Sept. 2004, pp. 1943–49. Pubmed, doi:10.1093/hmg/ddh202.
Sawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, De Jager PL, Gabriel S, Hafler DA, Ivinson AJ, Lander ES, Rioux JD, Walsh E, Gregory SG, Schmidt S, Pericak-Vance MA, Barcellos L, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL. Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Hum Mol Genet. 2004 Sep 1;13(17):1943–1949.
Journal cover image

Published In

Hum Mol Genet

DOI

ISSN

0964-6906

Publication Date

September 1, 2004

Volume

13

Issue

17

Start / End Page

1943 / 1949

Location

England

Related Subject Headings

  • United Kingdom
  • Polymorphism, Single Nucleotide
  • Multiple Sclerosis
  • Microsatellite Repeats
  • Humans
  • Genotype
  • Genetics & Heredity
  • Genetic Markers
  • Evaluation Studies as Topic
  • Chromosome Mapping