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Gabapentin and postoperative pain--a systematic review of randomized controlled trials.

Publication ,  Journal Article
Ho, K-Y; Gan, TJ; Habib, AS
Published in: Pain
December 15, 2006

The objective of this systematic review was to evaluate the efficacy and tolerability of perioperative gabapentin administration for the control of acute postoperative pain. We searched Medline (1966-2006), the Cochrane Library (2006), Scopus, CINAHL and bibliographies from clinical trials and review articles. We included randomized controlled trials (RCTs) comparing gabapentin with inactive controls in surgical patients. Sixteen valid RCTs were included. Weighted mean difference (WMD) for postoperative pain intensity (0-100 mm visual analogue scale) was -16.55 mm at 6 h and -10.87 mm at 24 h for treatment with a single preoperative dose of gabapentin 1200 mg. Cumulative opioid consumption at 24 h was also significantly decreased with gabapentin (WMD, -27.90 mg). When gabapentin was administered at doses less than 1200 mg, pain intensity was also lower at 6 h (WMD, -22.43 mm) and 24 h (WMD, -13.18 mm). Cumulative 24 h opioid consumption was also lower (WMD, -7.25 mg). Gabapentin was associated with an increased risk of sedation (Peto OR 3.86; 95% CI 2.50-5.94) but less opioid-related side effects such as vomiting (Peto OR 0.58; 95% CI 0.39-0.86) and pruritus (Peto OR 0.27; 95% CI 0.10-0.74). In conclusion, gabapentin has an analgesic and opioid-sparing effect in acute postoperative pain management when used in conjunction with opioids.

Duke Scholars

Published In

Pain

DOI

EISSN

1872-6623

Publication Date

December 15, 2006

Volume

126

Issue

1-3

Start / End Page

91 / 101

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Randomized Controlled Trials as Topic
  • Perioperative Care
  • Pain, Postoperative
  • Humans
  • Gabapentin
  • Cyclohexanecarboxylic Acids
  • Anesthesiology
  • Analgesics
  • Amines
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ho, K.-Y., Gan, T. J., & Habib, A. S. (2006). Gabapentin and postoperative pain--a systematic review of randomized controlled trials. Pain, 126(1–3), 91–101. https://doi.org/10.1016/j.pain.2006.06.018
Ho, Kok-Yuen, Tong J. Gan, and Ashraf S. Habib. “Gabapentin and postoperative pain--a systematic review of randomized controlled trials.Pain 126, no. 1–3 (December 15, 2006): 91–101. https://doi.org/10.1016/j.pain.2006.06.018.
Ho K-Y, Gan TJ, Habib AS. Gabapentin and postoperative pain--a systematic review of randomized controlled trials. Pain. 2006 Dec 15;126(1–3):91–101.
Ho, Kok-Yuen, et al. “Gabapentin and postoperative pain--a systematic review of randomized controlled trials.Pain, vol. 126, no. 1–3, Dec. 2006, pp. 91–101. Pubmed, doi:10.1016/j.pain.2006.06.018.
Ho K-Y, Gan TJ, Habib AS. Gabapentin and postoperative pain--a systematic review of randomized controlled trials. Pain. 2006 Dec 15;126(1–3):91–101.

Published In

Pain

DOI

EISSN

1872-6623

Publication Date

December 15, 2006

Volume

126

Issue

1-3

Start / End Page

91 / 101

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Randomized Controlled Trials as Topic
  • Perioperative Care
  • Pain, Postoperative
  • Humans
  • Gabapentin
  • Cyclohexanecarboxylic Acids
  • Anesthesiology
  • Analgesics
  • Amines