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Size and shape: the developmental regulation of static allometry in insects.

Publication ,  Journal Article
Shingleton, AW; Frankino, WA; Flatt, T; Nijhout, HF; Emlen, DJ
Published in: BioEssays : news and reviews in molecular, cellular and developmental biology
June 2007

Among all organisms, the size of each body part or organ scales with overall body size, a phenomenon called allometry. The study of shape and form has attracted enormous interest from biologists, but the genetic, developmental and physiological mechanisms that control allometry and the proportional growth of parts have remained elusive. Recent progress in our understanding of body-size regulation provides a new synthetic framework for thinking about the mechanisms and the evolution of allometric scaling. In particular, insulin/IGF signaling, which plays major roles in longevity, diabetes and the regulation of cell, organ and body size, might also be centrally involved in regulating organismal shape. Here we review recent advances in the fields of growth regulation and endocrinology and use them to construct a developmental model of static allometry expression in insects. This model serves as the foundation for a research program that will result in a deeper understanding of the relationship between growth and form, a question that has fascinated biologists for centuries.

Duke Scholars

Published In

BioEssays : news and reviews in molecular, cellular and developmental biology

DOI

EISSN

1521-1878

ISSN

0265-9247

Publication Date

June 2007

Volume

29

Issue

6

Start / End Page

536 / 548

Related Subject Headings

  • Insecta
  • Humans
  • Energy Intake
  • Diet
  • Developmental Biology
  • Body Size
  • Biological Evolution
  • Animals
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences
 

Citation

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ICMJE
MLA
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Shingleton, A. W., Frankino, W. A., Flatt, T., Nijhout, H. F., & Emlen, D. J. (2007). Size and shape: the developmental regulation of static allometry in insects. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology, 29(6), 536–548. https://doi.org/10.1002/bies.20584
Shingleton, Alexander W., W Anthony Frankino, Thomas Flatt, H Frederik Nijhout, and Douglas J. Emlen. “Size and shape: the developmental regulation of static allometry in insects.BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology 29, no. 6 (June 2007): 536–48. https://doi.org/10.1002/bies.20584.
Shingleton AW, Frankino WA, Flatt T, Nijhout HF, Emlen DJ. Size and shape: the developmental regulation of static allometry in insects. BioEssays : news and reviews in molecular, cellular and developmental biology. 2007 Jun;29(6):536–48.
Shingleton, Alexander W., et al. “Size and shape: the developmental regulation of static allometry in insects.BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology, vol. 29, no. 6, June 2007, pp. 536–48. Epmc, doi:10.1002/bies.20584.
Shingleton AW, Frankino WA, Flatt T, Nijhout HF, Emlen DJ. Size and shape: the developmental regulation of static allometry in insects. BioEssays : news and reviews in molecular, cellular and developmental biology. 2007 Jun;29(6):536–548.
Journal cover image

Published In

BioEssays : news and reviews in molecular, cellular and developmental biology

DOI

EISSN

1521-1878

ISSN

0265-9247

Publication Date

June 2007

Volume

29

Issue

6

Start / End Page

536 / 548

Related Subject Headings

  • Insecta
  • Humans
  • Energy Intake
  • Diet
  • Developmental Biology
  • Body Size
  • Biological Evolution
  • Animals
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences