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Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development.

Publication ,  Journal Article
Croce, J; Duloquin, L; Lhomond, G; McClay, DR; Gache, C
Published in: Development (Cambridge, England)
February 2006

Wnt signaling pathways play key roles in numerous developmental processes both in vertebrates and invertebrates. Their signals are transduced by Frizzled proteins, the cognate receptors of the Wnt ligands. This study focuses on the role of a member of the Frizzled family, Fz5/8, during sea urchin embryogenesis. During development, Fz5/8 displays restricted expression, beginning at the 60-cell stage in the animal domain and then from mesenchyme blastula stage, in both the animal domain and a subset of secondary mesenchyme cells (SMCs). Loss-of-function analyses in whole embryos and chimeras reveal that Fz5/8 is not involved in the specification of the main embryonic territories. Rather, it appears to be required in SMCs for primary invagination of the archenteron, maintenance of endodermal marker expression and apical localization of Notch receptors in endodermal cells. Furthermore, among the three known Wnt pathways, Fz5/8 appears to signal via the planar cell polarity pathway. Taken together, the results suggest that Fz5/8 plays a crucial role specifically in SMCs to control primary invagination during sea urchin gastrulation.

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Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

February 2006

Volume

133

Issue

3

Start / End Page

547 / 557

Related Subject Headings

  • Wnt Proteins
  • Signal Transduction
  • Sea Urchins
  • Receptors, Notch
  • Phylogeny
  • Mesoderm
  • Humans
  • Gene Expression Regulation, Developmental
  • Gastrula
  • Frizzled Receptors
 

Citation

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Croce, J., Duloquin, L., Lhomond, G., McClay, D. R., & Gache, C. (2006). Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development. Development (Cambridge, England), 133(3), 547–557. https://doi.org/10.1242/dev.02218
Croce, Jenifer, Louise Duloquin, Guy Lhomond, David R. McClay, and Christian Gache. “Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development.Development (Cambridge, England) 133, no. 3 (February 2006): 547–57. https://doi.org/10.1242/dev.02218.
Croce J, Duloquin L, Lhomond G, McClay DR, Gache C. Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development. Development (Cambridge, England). 2006 Feb;133(3):547–57.
Croce, Jenifer, et al. “Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development.Development (Cambridge, England), vol. 133, no. 3, Feb. 2006, pp. 547–57. Epmc, doi:10.1242/dev.02218.
Croce J, Duloquin L, Lhomond G, McClay DR, Gache C. Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development. Development (Cambridge, England). 2006 Feb;133(3):547–557.
Journal cover image

Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

February 2006

Volume

133

Issue

3

Start / End Page

547 / 557

Related Subject Headings

  • Wnt Proteins
  • Signal Transduction
  • Sea Urchins
  • Receptors, Notch
  • Phylogeny
  • Mesoderm
  • Humans
  • Gene Expression Regulation, Developmental
  • Gastrula
  • Frizzled Receptors