Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles.
Publication
, Journal Article
Liu, C; Widenhoefer, RA
Published in: Organic letters
May 2007
Treatment of 2-allenyl indole 4 with a catalytic 1:2 mixture of [(S)-2]Au2Cl2 [(S)-2 = (S)-3,5-tBu-4-MeO-MeOBIPHEP] and AgBF4 in toluene at -10 degrees C for 17 h led to isolation of tetrahydrocarbazole 5 in 88% yield with 92% ee. The protocol was effective for the cyclization of terminally disubstituted allenes and for the formation of seven-membered rings.
Duke Scholars
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Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
May 2007
Volume
9
Issue
10
Start / End Page
1935 / 1938
Related Subject Headings
- Stereoisomerism
- Solvents
- Silver
- Organic Chemistry
- Molecular Structure
- Ligands
- Indoles
- Hydrogen
- Gold
- Catalysis
Citation
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Chicago
ICMJE
MLA
NLM
Liu, C., & Widenhoefer, R. A. (2007). Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles. Organic Letters, 9(10), 1935–1938. https://doi.org/10.1021/ol070483c
Liu, Cong, and Ross A. Widenhoefer. “Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles.” Organic Letters 9, no. 10 (May 2007): 1935–38. https://doi.org/10.1021/ol070483c.
Liu C, Widenhoefer RA. Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles. Organic letters. 2007 May;9(10):1935–8.
Liu, Cong, and Ross A. Widenhoefer. “Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles.” Organic Letters, vol. 9, no. 10, May 2007, pp. 1935–38. Epmc, doi:10.1021/ol070483c.
Liu C, Widenhoefer RA. Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles. Organic letters. 2007 May;9(10):1935–1938.
Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
May 2007
Volume
9
Issue
10
Start / End Page
1935 / 1938
Related Subject Headings
- Stereoisomerism
- Solvents
- Silver
- Organic Chemistry
- Molecular Structure
- Ligands
- Indoles
- Hydrogen
- Gold
- Catalysis