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A framework to evaluate the economic impact of pharmacogenomics.

Publication ,  Journal Article
Stallings, SC; Huse, D; Finkelstein, SN; Crown, WH; Witt, WP; Maguire, J; Hiller, AJ; Sinskey, AJ; Ginsburg, GS
Published in: Pharmacogenomics
September 2006

INTRODUCTION: Pharmacogenomics and personalized medicine promise to improve healthcare by increasing drug efficacy and minimizing side effects. There may also be substantial savings realized by eliminating costs associated with failed treatment. This paper describes a framework using health claims data for analyzing the potential value of pharmacogenomic testing in clinical practice. METHODS: We evaluated a model of alternate clinical strategies using asthma patients' data from a retrospective health claims database to determine a potential cost offset. We estimated the likely cost impact of using a hypothetical pharmacogenomic test to determine a preferred initial therapy. We compared the annualized per patient costs distributions under two clinical strategies: testing all patients for a nonresponse genotype prior to treating and testing none. RESULTS: In the Test All strategy, more patients fall into lower cost ranges of the distribution. In our base case (15% phenotype prevalence, 200 US dollars test, 74% overall first-line treatment efficacy and 60% second-line therapy efficacy) the cost savings per patient for a typical run of the testing strategy simulation ranged from 200 US dollars to 767 US dollars (5th and 95th percentile). Genetic variant prevalence, test cost and the cost of choosing the wrong treatment are key parameters in the economic viability of pharmacogenomics in clinical practice. CONCLUSIONS: A general tool for predicting the impact of pharmacogenomic-based diagnostic tests on healthcare costs in asthma patients suggests that upfront testing costs are likely offset by avoided nonresponse costs. We suggest that similar analyses for decision making could be undertaken using claims data in which a population can be stratified by response to a drug.

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Published In

Pharmacogenomics

DOI

ISSN

1462-2416

Publication Date

September 2006

Volume

7

Issue

6

Start / End Page

853 / 862

Location

England

Related Subject Headings

  • Retrospective Studies
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Models, Economic
  • Humans
  • Databases, Factual
  • Cost Savings
  • Asthma
  • Anti-Asthmatic Agents
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Stallings, S. C., Huse, D., Finkelstein, S. N., Crown, W. H., Witt, W. P., Maguire, J., … Ginsburg, G. S. (2006). A framework to evaluate the economic impact of pharmacogenomics. Pharmacogenomics, 7(6), 853–862. https://doi.org/10.2217/14622416.7.6.853
Stallings, Sarah C., Dan Huse, Stan N. Finkelstein, William H. Crown, Whitney P. Witt, Jon Maguire, Arthur J. Hiller, Anthony J. Sinskey, and Geoffrey S. Ginsburg. “A framework to evaluate the economic impact of pharmacogenomics.Pharmacogenomics 7, no. 6 (September 2006): 853–62. https://doi.org/10.2217/14622416.7.6.853.
Stallings SC, Huse D, Finkelstein SN, Crown WH, Witt WP, Maguire J, et al. A framework to evaluate the economic impact of pharmacogenomics. Pharmacogenomics. 2006 Sep;7(6):853–62.
Stallings, Sarah C., et al. “A framework to evaluate the economic impact of pharmacogenomics.Pharmacogenomics, vol. 7, no. 6, Sept. 2006, pp. 853–62. Pubmed, doi:10.2217/14622416.7.6.853.
Stallings SC, Huse D, Finkelstein SN, Crown WH, Witt WP, Maguire J, Hiller AJ, Sinskey AJ, Ginsburg GS. A framework to evaluate the economic impact of pharmacogenomics. Pharmacogenomics. 2006 Sep;7(6):853–862.
Journal cover image

Published In

Pharmacogenomics

DOI

ISSN

1462-2416

Publication Date

September 2006

Volume

7

Issue

6

Start / End Page

853 / 862

Location

England

Related Subject Headings

  • Retrospective Studies
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Models, Economic
  • Humans
  • Databases, Factual
  • Cost Savings
  • Asthma
  • Anti-Asthmatic Agents
  • 3214 Pharmacology and pharmaceutical sciences