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Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications.

Publication ,  Journal Article
Seo, D; Ginsburg, GS; Goldschmidt-Clermont, PJ
Published in: J Am Coll Cardiol
July 18, 2006

Although the contribution of genetics to complex cardiovascular diseases such as atherosclerosis has been accepted for quite some time, full and detailed knowledge of the individual causative genes has been elusive. With the advent of genomic technologies and methods, the necessary tools are now available to begin pinpointing the genes that contribute to disease susceptibility and progression. One approach being applied extensively in candidate gene discovery is gene expression analysis of human and animal tissues using microarrays. The genes identified by these genomic studies provide valuable insight into disease biology and represent the initial steps toward the development of diagnostic tests and therapeutic strategies that will substantially improve human health. This paper highlights the progress that has been made in using gene expression analysis cardiovascular genomic research and the potential for applying these findings in clinical medicine.

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

July 18, 2006

Volume

48

Issue

2

Start / End Page

227 / 235

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Pharmacogenetics
  • Oligonucleotide Array Sequence Analysis
  • Neutrophils
  • Hypertension
  • Humans
  • Heart Transplantation
  • Heart Failure
  • Gene Expression Profiling
  • Coronary Artery Disease
 

Citation

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Seo, D., Ginsburg, G. S., & Goldschmidt-Clermont, P. J. (2006). Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications. J Am Coll Cardiol, 48(2), 227–235. https://doi.org/10.1016/j.jacc.2006.02.070
Seo, David, Geoffrey S. Ginsburg, and Pascal J. Goldschmidt-Clermont. “Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications.J Am Coll Cardiol 48, no. 2 (July 18, 2006): 227–35. https://doi.org/10.1016/j.jacc.2006.02.070.
Seo D, Ginsburg GS, Goldschmidt-Clermont PJ. Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications. J Am Coll Cardiol. 2006 Jul 18;48(2):227–35.
Seo, David, et al. “Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications.J Am Coll Cardiol, vol. 48, no. 2, July 2006, pp. 227–35. Pubmed, doi:10.1016/j.jacc.2006.02.070.
Seo D, Ginsburg GS, Goldschmidt-Clermont PJ. Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications. J Am Coll Cardiol. 2006 Jul 18;48(2):227–235.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

July 18, 2006

Volume

48

Issue

2

Start / End Page

227 / 235

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Pharmacogenetics
  • Oligonucleotide Array Sequence Analysis
  • Neutrophils
  • Hypertension
  • Humans
  • Heart Transplantation
  • Heart Failure
  • Gene Expression Profiling
  • Coronary Artery Disease