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The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus.

Publication ,  Journal Article
Levesque, MC; Weinberg, JB
Published in: Curr Mol Med
November 2004

Atherosclerosis is an inflammatory disorder, and the inflammation associated with systemic lupus erythematosus (SLE) accelerates the development of atherosclerosis. Nitric oxide (NO) is an important mediator of inflammation including the inflammation associated with atherosclerosis and SLE. Endothelial nitric oxide synthase (NOS3)-mediated constitutive expression of NO promotes endothelial integrity and normal vascular function. In contrast, inducible nitric oxide synthase- (NOS2) mediated expression of NO promotes endothelial dysfunction and atherogenesis. Statins appear to have anti-inflammatory properties and reverse many of the deleterious effects associated with NO metabolism in atherosclerosis. Statins augment NOS3 expression and inhibit the induction of NOS2. Therefore, the balance between normal vascular function and atherogenesis may be mediated by differences in the quantity, location, and timing of NO production within vessel walls.

Duke Scholars

Published In

Curr Mol Med

DOI

ISSN

1566-5240

Publication Date

November 2004

Volume

4

Issue

7

Start / End Page

777 / 786

Location

Netherlands

Related Subject Headings

  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Lupus Erythematosus, Systemic
  • Inflammation
  • Immunology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Endothelium
 

Citation

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MLA
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Levesque, M. C., & Weinberg, J. B. (2004). The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus. Curr Mol Med, 4(7), 777–786. https://doi.org/10.2174/1566524043359872
Levesque, Marc C., and J Brice Weinberg. “The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus.Curr Mol Med 4, no. 7 (November 2004): 777–86. https://doi.org/10.2174/1566524043359872.
Levesque, Marc C., and J. Brice Weinberg. “The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus.Curr Mol Med, vol. 4, no. 7, Nov. 2004, pp. 777–86. Pubmed, doi:10.2174/1566524043359872.
Journal cover image

Published In

Curr Mol Med

DOI

ISSN

1566-5240

Publication Date

November 2004

Volume

4

Issue

7

Start / End Page

777 / 786

Location

Netherlands

Related Subject Headings

  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Lupus Erythematosus, Systemic
  • Inflammation
  • Immunology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Endothelium