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SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.

Publication ,  Journal Article
Ding, X; Xu, R; Yu, J; Xu, T; Zhuang, Y; Han, M
Published in: Dev Cell
June 2007

Prior to the pairing and recombination between homologous chromosomes during meiosis, telomeres attach to the nuclear envelope and form a transient cluster. However, the protein factors mediating meiotic telomere attachment to the nuclear envelope and the requirement of this attachment for homolog pairing and synapsis have not been determined in animals. Here we show that the inner nuclear membrane protein SUN1 specifically associates with telomeres between the leptotene and diplotene stages during meiotic prophase I. Disruption of Sun1 in mice prevents telomere attachment to the nuclear envelope, efficient homolog pairing, and synapsis formation in meiosis. Massive apoptotic events are induced in the mutant gonads, leading to the abolishment of both spermatogenesis and oogenesis. This study provides genetic evidence that SUN1-telomere interaction is essential for telomere dynamic movement and is required for efficient homologous chromosome pairing/synapsis during mammalian gametogenesis.

Duke Scholars

Published In

Dev Cell

DOI

ISSN

1534-5807

Publication Date

June 2007

Volume

12

Issue

6

Start / End Page

863 / 872

Location

United States

Related Subject Headings

  • Telomere
  • Recombination, Genetic
  • Protein Transport
  • Oogenesis
  • Nuclear Envelope
  • Microtubule-Associated Proteins
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Meiotic Prophase I
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ding, X., Xu, R., Yu, J., Xu, T., Zhuang, Y., & Han, M. (2007). SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell, 12(6), 863–872. https://doi.org/10.1016/j.devcel.2007.03.018
Ding, Xu, Rener Xu, Juehua Yu, Tian Xu, Yuan Zhuang, and Min Han. “SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.Dev Cell 12, no. 6 (June 2007): 863–72. https://doi.org/10.1016/j.devcel.2007.03.018.
Ding X, Xu R, Yu J, Xu T, Zhuang Y, Han M. SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell. 2007 Jun;12(6):863–72.
Ding, Xu, et al. “SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.Dev Cell, vol. 12, no. 6, June 2007, pp. 863–72. Pubmed, doi:10.1016/j.devcel.2007.03.018.
Ding X, Xu R, Yu J, Xu T, Zhuang Y, Han M. SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell. 2007 Jun;12(6):863–872.
Journal cover image

Published In

Dev Cell

DOI

ISSN

1534-5807

Publication Date

June 2007

Volume

12

Issue

6

Start / End Page

863 / 872

Location

United States

Related Subject Headings

  • Telomere
  • Recombination, Genetic
  • Protein Transport
  • Oogenesis
  • Nuclear Envelope
  • Microtubule-Associated Proteins
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Meiotic Prophase I