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The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo.

Publication ,  Journal Article
Hantz, O; Périgaud, C; Borel, C; Jamard, C; Zoulim, F; Trépo, C; Imbach, JL; Gosselin, G
Published in: Antiviral Res
January 1999

The in vitro and in vivo antiviral activities of two mononucleoside phosphotriester derivatives of acyclovir (ACV) incorporating S-acyl-2-thioethyl (SATE) groups are reported using the duck model of hepatitis B (DHBV). In primary duck hepatocyte cultures, the described phosphotriesters significantly inhibited the replication of DHBV at submicromolar concentrations. They were found to be more potent than the parent nucleoside. This result was in agreement with our data concerning the anti-HBV activity of these pronucleotides in HepG2.2.15 cells (previous paper). In vivo, the studied SATE pronucleotide was also found to be more efficient than ACV in infected ducklings upon short-term oral therapy, while intraperitoneal treatment showed high anti-DHBV activity with both ACV and its SATE pronucleotide in this animal model. These findings demonstrate the potential of SATE pronucleotides of ACV as anti-HBV agents.

Duke Scholars

Published In

Antiviral Res

DOI

ISSN

0166-3542

Publication Date

January 1999

Volume

40

Issue

3

Start / End Page

179 / 187

Location

Netherlands

Related Subject Headings

  • Virus Replication
  • Virology
  • Prodrugs
  • Organophosphonates
  • Nucleotides
  • Liver
  • Hepatitis B Virus, Duck
  • Hepadnaviridae Infections
  • Ducks
  • Drug Evaluation, Preclinical
 

Citation

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Hantz, O., Périgaud, C., Borel, C., Jamard, C., Zoulim, F., Trépo, C., … Gosselin, G. (1999). The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo. Antiviral Res, 40(3), 179–187. https://doi.org/10.1016/s0166-3542(98)00060-6
Hantz, O., C. Périgaud, C. Borel, C. Jamard, F. Zoulim, C. Trépo, J. L. Imbach, and G. Gosselin. “The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo.Antiviral Res 40, no. 3 (January 1999): 179–87. https://doi.org/10.1016/s0166-3542(98)00060-6.
Hantz, O., et al. “The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo.Antiviral Res, vol. 40, no. 3, Jan. 1999, pp. 179–87. Pubmed, doi:10.1016/s0166-3542(98)00060-6.
Hantz O, Périgaud C, Borel C, Jamard C, Zoulim F, Trépo C, Imbach JL, Gosselin G. The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo. Antiviral Res. 1999 Jan;40(3):179–187.
Journal cover image

Published In

Antiviral Res

DOI

ISSN

0166-3542

Publication Date

January 1999

Volume

40

Issue

3

Start / End Page

179 / 187

Location

Netherlands

Related Subject Headings

  • Virus Replication
  • Virology
  • Prodrugs
  • Organophosphonates
  • Nucleotides
  • Liver
  • Hepatitis B Virus, Duck
  • Hepadnaviridae Infections
  • Ducks
  • Drug Evaluation, Preclinical