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Effects of liver growth factors on hepadnavirus replication in chronically infected duck hepatocytes.

Publication ,  Journal Article
Schorr, O; Borel, C; Trepo, C; Zoulim, F; Hantz, O
Published in: J Hepatol
May 2006

BACKGROUND/AIMS: Duck hepatitis B virus (DHBV) replication is up-regulated by cell cycle during the early infection of primary duck but the effect of cell cycle on DHBV replication in chronically infected hepatocyte is not known. METHODS: Hepatocytes obtained from DHBV congenitally infected embryos were used. Cell proliferation was controlled by addition of liver growth factors and the impact on viral replication analyzed. RESULTS: EGF induced cell proliferation is associated with a slight increase in CCC DNA synthesis and a decrease in viral transcription. Conversely, TGFbeta blocked cell cycle progression, diminished CCC DNA synthesis but increased viral transcription. CONCLUSIONS: Cell proliferation decreases DHBV transcription but this effect seems to be compensated by an opposite effect on the synthesis of CCC DNA resulting in a global moderate effect on viral replication. Our results also indicate that after division of chronically infected hepatocytes both daughter cells are infected, confirming that liver regeneration is not sufficient to induce CCC DNA eradication as suggested by the lack of effect of some long term anti-HBV therapies.

Duke Scholars

Published In

J Hepatol

DOI

ISSN

0168-8278

Publication Date

May 2006

Volume

44

Issue

5

Start / End Page

842 / 847

Location

Netherlands

Related Subject Headings

  • Virus Replication
  • Transforming Growth Factor beta
  • Transcription, Genetic
  • RNA, Viral
  • Liver Regeneration
  • Hepatocytes
  • Hepatitis, Viral, Animal
  • Hepatitis B Virus, Duck
  • Hepadnaviridae Infections
  • Gene Expression Regulation, Viral
 

Citation

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Schorr, O., Borel, C., Trepo, C., Zoulim, F., & Hantz, O. (2006). Effects of liver growth factors on hepadnavirus replication in chronically infected duck hepatocytes. J Hepatol, 44(5), 842–847. https://doi.org/10.1016/j.jhep.2005.09.014
Schorr, Olivier, Christelle Borel, Christian Trepo, Fabien Zoulim, and Olivier Hantz. “Effects of liver growth factors on hepadnavirus replication in chronically infected duck hepatocytes.J Hepatol 44, no. 5 (May 2006): 842–47. https://doi.org/10.1016/j.jhep.2005.09.014.
Schorr O, Borel C, Trepo C, Zoulim F, Hantz O. Effects of liver growth factors on hepadnavirus replication in chronically infected duck hepatocytes. J Hepatol. 2006 May;44(5):842–7.
Schorr, Olivier, et al. “Effects of liver growth factors on hepadnavirus replication in chronically infected duck hepatocytes.J Hepatol, vol. 44, no. 5, May 2006, pp. 842–47. Pubmed, doi:10.1016/j.jhep.2005.09.014.
Schorr O, Borel C, Trepo C, Zoulim F, Hantz O. Effects of liver growth factors on hepadnavirus replication in chronically infected duck hepatocytes. J Hepatol. 2006 May;44(5):842–847.
Journal cover image

Published In

J Hepatol

DOI

ISSN

0168-8278

Publication Date

May 2006

Volume

44

Issue

5

Start / End Page

842 / 847

Location

Netherlands

Related Subject Headings

  • Virus Replication
  • Transforming Growth Factor beta
  • Transcription, Genetic
  • RNA, Viral
  • Liver Regeneration
  • Hepatocytes
  • Hepatitis, Viral, Animal
  • Hepatitis B Virus, Duck
  • Hepadnaviridae Infections
  • Gene Expression Regulation, Viral