SRY and the standoff in sex determination.
Publication
, Journal Article
DiNapoli, L; Capel, B
Published in: Mol Endocrinol
January 2008
SRY was identified as the mammalian sex-determining gene more than 15 yr ago and has been extensively studied since. Although many of the pathways regulating sexual differentiation have been elucidated, direct downstream targets of SRY are still unclear, making a top down approach difficult. However, recent work has demonstrated that the fate of the gonad is actively contested by both male-promoting and female-promoting signals. Sox9 and Fgf9 push gonads towards testis differentiation. These two genes are opposed by Wnt4, and possibly RSPO1, which push gonads toward ovary differentiation. In this review, we will discuss the history of the field, current findings, and exciting new directions in vertebrate sex determination.
Duke Scholars
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Published In
Mol Endocrinol
DOI
ISSN
0888-8809
Publication Date
January 2008
Volume
22
Issue
1
Start / End Page
1 / 9
Location
United States
Related Subject Headings
- Sex-Determining Region Y Protein
- Sex Determination Processes
- Sex Chromosomes
- Models, Biological
- Male
- Gonads
- Female
- Endocrinology & Metabolism
- Cell Differentiation
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
DiNapoli, L., & Capel, B. (2008). SRY and the standoff in sex determination. Mol Endocrinol, 22(1), 1–9. https://doi.org/10.1210/me.2007-0250
DiNapoli, Leo, and Blanche Capel. “SRY and the standoff in sex determination.” Mol Endocrinol 22, no. 1 (January 2008): 1–9. https://doi.org/10.1210/me.2007-0250.
DiNapoli L, Capel B. SRY and the standoff in sex determination. Mol Endocrinol. 2008 Jan;22(1):1–9.
DiNapoli, Leo, and Blanche Capel. “SRY and the standoff in sex determination.” Mol Endocrinol, vol. 22, no. 1, Jan. 2008, pp. 1–9. Pubmed, doi:10.1210/me.2007-0250.
DiNapoli L, Capel B. SRY and the standoff in sex determination. Mol Endocrinol. 2008 Jan;22(1):1–9.
Published In
Mol Endocrinol
DOI
ISSN
0888-8809
Publication Date
January 2008
Volume
22
Issue
1
Start / End Page
1 / 9
Location
United States
Related Subject Headings
- Sex-Determining Region Y Protein
- Sex Determination Processes
- Sex Chromosomes
- Models, Biological
- Male
- Gonads
- Female
- Endocrinology & Metabolism
- Cell Differentiation
- Animals