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AMH induces mesonephric cell migration in XX gonads.

Publication ,  Journal Article
Ross, AJ; Tilman, C; Yao, H; MacLaughlin, D; Capel, B
Published in: Mol Cell Endocrinol
December 15, 2003

Migration of mesonephric cells into XY gonads is a critical early event in testis cord formation. Based on the fact that anti-Müllerian hormone (AMH) can induce testis cord formation in XX gonads, we investigated whether AMH plays a role in the induction of cell migration. Addition of recombinant AMH induced mesonephric migration into XX gonads in culture. AMH-treated XX gonads displayed increased vascular development and altered morphology of the coelomic epithelium, both features of normal testis differentiation. AMH did not induce markers of Sertoli or Leydig cell differentiation. We examined early testis development in Amh-deficient mice, but found no abnormalities, suggesting that any function AMH may have in vivo is redundant. Other transforming growth factor (TGF-beta) family proteins, bone morphogenetic proteins (BMP2 and BMP4) show similar inductive effects on XX gonads in culture. Although neither BMP2 nor BMP4 is expressed in embryonic XY gonads, our findings suggest that a TGF-beta signalling pathway endogenous to the XY gonad may be involved in regulation of mesonephric cell migration. The factors involved in this process remain to be identified.

Duke Scholars

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

December 15, 2003

Volume

211

Issue

1-2

Start / End Page

1 / 7

Location

Ireland

Related Subject Headings

  • beta-Galactosidase
  • Transforming Growth Factor beta
  • Transcription Factors
  • Testicular Hormones
  • Sex Differentiation
  • SOX9 Transcription Factor
  • Recombinant Proteins
  • Receptors, Transforming Growth Factor beta
  • Receptors, Peptide
  • Platelet Endothelial Cell Adhesion Molecule-1
 

Citation

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ICMJE
MLA
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Ross, A. J., Tilman, C., Yao, H., MacLaughlin, D., & Capel, B. (2003). AMH induces mesonephric cell migration in XX gonads. Mol Cell Endocrinol, 211(1–2), 1–7. https://doi.org/10.1016/j.mce.2003.09.021
Ross, Andrea J., Christopher Tilman, Humphrey Yao, David MacLaughlin, and Blanche Capel. “AMH induces mesonephric cell migration in XX gonads.Mol Cell Endocrinol 211, no. 1–2 (December 15, 2003): 1–7. https://doi.org/10.1016/j.mce.2003.09.021.
Ross AJ, Tilman C, Yao H, MacLaughlin D, Capel B. AMH induces mesonephric cell migration in XX gonads. Mol Cell Endocrinol. 2003 Dec 15;211(1–2):1–7.
Ross, Andrea J., et al. “AMH induces mesonephric cell migration in XX gonads.Mol Cell Endocrinol, vol. 211, no. 1–2, Dec. 2003, pp. 1–7. Pubmed, doi:10.1016/j.mce.2003.09.021.
Ross AJ, Tilman C, Yao H, MacLaughlin D, Capel B. AMH induces mesonephric cell migration in XX gonads. Mol Cell Endocrinol. 2003 Dec 15;211(1–2):1–7.
Journal cover image

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

December 15, 2003

Volume

211

Issue

1-2

Start / End Page

1 / 7

Location

Ireland

Related Subject Headings

  • beta-Galactosidase
  • Transforming Growth Factor beta
  • Transcription Factors
  • Testicular Hormones
  • Sex Differentiation
  • SOX9 Transcription Factor
  • Recombinant Proteins
  • Receptors, Transforming Growth Factor beta
  • Receptors, Peptide
  • Platelet Endothelial Cell Adhesion Molecule-1