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Multistage designs in the genomic era: providing balance in complex disease studies.

Publication ,  Journal Article
Dubé, M-P; Schmidt, S; Hauser, E; Darabi, H; Li, J; Barhdadi, A; Wang, X; Sha, Q; Zhang, Z; Wang, T; Aschard, H; Guedj, M; Rohlfs, R ...
Published in: Genet Epidemiol
2007

In this summary paper, we describe the contributions included in the Multistage Design group (Group 14) at the Genetic Analysis Workshop 15, which was held during November 12-14, 2006. Our group contrasted and compared different approaches to reducing complexity in a genetic study through implementation of staged designs. Most groups used the simulated dataset (problem 3), which provided ample opportunities for evaluating various staged designs. A wide range of multistage designs that targeted different aspects of complexity were explored. We categorized these approaches as reducing phenotypic complexity, model complexity, analytic complexity or genetic complexity. In general we learned that: (1) when staged designs are carefully planned and implemented, the power loss compared to a single-stage analysis can be minimized and study cost is greatly reduced; (2) a joint analysis of the results from each stage is generally more powerful than treating the second stage as a replication analysis.

Duke Scholars

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

2007

Volume

31 Suppl 1

Issue

Suppl 1

Start / End Page

S118 / S123

Location

United States

Related Subject Headings

  • Research Design
  • Phenotype
  • Models, Genetic
  • Humans
  • Genome, Human
  • Epidemiology
  • 4202 Epidemiology
  • 3105 Genetics
  • 1117 Public Health and Health Services
  • 0604 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dubé, M.-P., Schmidt, S., Hauser, E., Darabi, H., Li, J., Barhdadi, A., … Sinha, R. (2007). Multistage designs in the genomic era: providing balance in complex disease studies. Genet Epidemiol, 31 Suppl 1(Suppl 1), S118–S123. https://doi.org/10.1002/gepi.20288
Dubé, Marie-Pierre, Silke Schmidt, Elizabeth Hauser, Hatef Darabi, Jing Li, Amina Barhdadi, Xuexia Wang, et al. “Multistage designs in the genomic era: providing balance in complex disease studies.Genet Epidemiol 31 Suppl 1, no. Suppl 1 (2007): S118–23. https://doi.org/10.1002/gepi.20288.
Dubé M-P, Schmidt S, Hauser E, Darabi H, Li J, Barhdadi A, et al. Multistage designs in the genomic era: providing balance in complex disease studies. Genet Epidemiol. 2007;31 Suppl 1(Suppl 1):S118–23.
Dubé, Marie-Pierre, et al. “Multistage designs in the genomic era: providing balance in complex disease studies.Genet Epidemiol, vol. 31 Suppl 1, no. Suppl 1, 2007, pp. S118–23. Pubmed, doi:10.1002/gepi.20288.
Dubé M-P, Schmidt S, Hauser E, Darabi H, Li J, Barhdadi A, Wang X, Sha Q, Zhang Z, Wang T, Aschard H, Guedj M, Rohlfs R, Anderson A, Taylor C, Mirea L, Nickolov R, Milanov V, Yang H-C, Song Y, Sinha R. Multistage designs in the genomic era: providing balance in complex disease studies. Genet Epidemiol. 2007;31 Suppl 1(Suppl 1):S118–S123.
Journal cover image

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

2007

Volume

31 Suppl 1

Issue

Suppl 1

Start / End Page

S118 / S123

Location

United States

Related Subject Headings

  • Research Design
  • Phenotype
  • Models, Genetic
  • Humans
  • Genome, Human
  • Epidemiology
  • 4202 Epidemiology
  • 3105 Genetics
  • 1117 Public Health and Health Services
  • 0604 Genetics