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The use of lithium carbonate to reduce infection and leukopenia during systemic chemotherapy.

Publication ,  Journal Article
Lyman, GH; Williams, CC; Preston, D
Published in: N Engl J Med
January 31, 1980

To investigate whether lithium ameliorates the infectious complications that accompany systemic chemotherapy, we studied 45 patients with small-cell bronchogenic carcinoma receiving combination chemotherapy and radiation therapy. Twenty received lithium carbonate, and 25 received no additional therapy. Control subjects experienced more days with neutropenia than the lithium-treated group (2.17 days per 100 patient-days vs. 0.29), more severe febrile episodes (seven patients vs. one patient), more days hospitalized with fever and neutropenia (1.92 per 100 patient-days vs. 0.18), and more infection-related deaths (five vs. none). Infection-free survival was significantly longer in the lithium-treated group than in controls (P less than 0.05). Delay in subsequent chemotherapy was longer (P less than 0.01) and the number of dose reductions greater (P less than 0.01) in the control group. For both leukocytes and neutrophils, the first cycle nadir, mean of all treatment nadirs, and the lowest nadir observed during treatment were significantly higher in the lithium group. Mean mid-cycle monocyte counts were greater in the lithium group (P less than 0.05) and correlated with concurrent serum lithium levels (rs = 0.74, P less than 0.05). We believe that lithium carbonate shows promise as a means of lowering the risk of infection among patients receiving cytotoxic therapy.

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Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

January 31, 1980

Volume

302

Issue

5

Start / End Page

257 / 260

Location

United States

Related Subject Headings

  • Vincristine
  • Random Allocation
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Lithium
  • Leukopenia
  • Leukocyte Count
  • Infections
  • Infection Control
 

Citation

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Lyman, G. H., Williams, C. C., & Preston, D. (1980). The use of lithium carbonate to reduce infection and leukopenia during systemic chemotherapy. N Engl J Med, 302(5), 257–260. https://doi.org/10.1056/NEJM198001313020503
Lyman, G. H., C. C. Williams, and D. Preston. “The use of lithium carbonate to reduce infection and leukopenia during systemic chemotherapy.N Engl J Med 302, no. 5 (January 31, 1980): 257–60. https://doi.org/10.1056/NEJM198001313020503.
Lyman GH, Williams CC, Preston D. The use of lithium carbonate to reduce infection and leukopenia during systemic chemotherapy. N Engl J Med. 1980 Jan 31;302(5):257–60.
Lyman, G. H., et al. “The use of lithium carbonate to reduce infection and leukopenia during systemic chemotherapy.N Engl J Med, vol. 302, no. 5, Jan. 1980, pp. 257–60. Pubmed, doi:10.1056/NEJM198001313020503.
Lyman GH, Williams CC, Preston D. The use of lithium carbonate to reduce infection and leukopenia during systemic chemotherapy. N Engl J Med. 1980 Jan 31;302(5):257–260.
Journal cover image

Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

January 31, 1980

Volume

302

Issue

5

Start / End Page

257 / 260

Location

United States

Related Subject Headings

  • Vincristine
  • Random Allocation
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Lithium
  • Leukopenia
  • Leukocyte Count
  • Infections
  • Infection Control