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Serum cholesterol reduction with tamoxifen.

Publication ,  Journal Article
Schapira, DV; Kumar, NB; Lyman, GH
Published in: Breast Cancer Res Treat
November 1990

The serum cholesterol levels of 123 consecutively and newly diagnosed women with Stage I and II breast cancer taking tamoxifen were compared with a control group of 81 consecutively newly diagnosed women with Stage I and II breast cancer who were not taking a hormonal treatment or supplement. Other factors that were evaluated were age, menopausal status, tumor size, weight, height, Quetelet index, and smoking and alcohol intake history. The mean cholesterol change in patients on tamoxifen (34.2 +/- 3.6 mg/dl) was significantly greater than controls (1.0 +/- 4.1 mg/dl) (P less than 0.001). Serum cholesterol fell by more than 10 mg/dl in 72.9% of women on tamoxifen vs. 35.1% of controls and by more than 40 mg/dl in 39.9% of women on tamoxifen vs. 12.6% of controls. Multivariate analysis revealed that tamoxifen administration (P less than 0.0001), initial cholesterol level (P = 0.001), and age (P = 0.04) were significant factors in producing a decrease in serum cholesterol. The administration of tamoxifen as adjuvant therapy to women with newly diagnosed breast cancer resulted in a significant fall in serum cholesterol. This effect of tamoxifen on the serum cholesterol may prove to be an additional benefit in the form of reduced cardiovascular risk in these women.

Duke Scholars

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

November 1990

Volume

17

Issue

1

Start / End Page

3 / 7

Location

Netherlands

Related Subject Headings

  • Tamoxifen
  • Risk Factors
  • Oncology & Carcinogenesis
  • Middle Aged
  • Liver
  • Humans
  • Female
  • Depression, Chemical
  • Cholesterol
  • Cardiovascular Diseases
 

Citation

APA
Chicago
ICMJE
MLA
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Schapira, D. V., Kumar, N. B., & Lyman, G. H. (1990). Serum cholesterol reduction with tamoxifen. Breast Cancer Res Treat, 17(1), 3–7. https://doi.org/10.1007/BF01812678
Schapira, D. V., N. B. Kumar, and G. H. Lyman. “Serum cholesterol reduction with tamoxifen.Breast Cancer Res Treat 17, no. 1 (November 1990): 3–7. https://doi.org/10.1007/BF01812678.
Schapira DV, Kumar NB, Lyman GH. Serum cholesterol reduction with tamoxifen. Breast Cancer Res Treat. 1990 Nov;17(1):3–7.
Schapira, D. V., et al. “Serum cholesterol reduction with tamoxifen.Breast Cancer Res Treat, vol. 17, no. 1, Nov. 1990, pp. 3–7. Pubmed, doi:10.1007/BF01812678.
Schapira DV, Kumar NB, Lyman GH. Serum cholesterol reduction with tamoxifen. Breast Cancer Res Treat. 1990 Nov;17(1):3–7.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

November 1990

Volume

17

Issue

1

Start / End Page

3 / 7

Location

Netherlands

Related Subject Headings

  • Tamoxifen
  • Risk Factors
  • Oncology & Carcinogenesis
  • Middle Aged
  • Liver
  • Humans
  • Female
  • Depression, Chemical
  • Cholesterol
  • Cardiovascular Diseases