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Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy.

Publication ,  Journal Article
Lyman, GH; Morrison, VA; Dale, DC; Crawford, J; Delgado, DJ; Fridman, M; OPPS Working Group, ; ANC Study Group,
Published in: Leuk Lymphoma
December 2003

We sought to identify risk factors associated with the time to febrile neutropenia in patients with intermediate-grade, non-Hodgkin's lymphoma (NHL) who were receiving treatment with CHOP chemotherapy. Data were collected from 12 community and academic oncology practices participating in the Oncology Practice Pattern Study between 1991 and 1999. We reviewed the medical records of 577 intermediate-grade NHL patients who received initial CHOP chemotherapy and evaluated risk factors associated with time to first febrile neutropenic event. A febrile neutropenic event was defined as a body temperature of > 100.6 degrees F and an ANC nadir < 1000/mm3. A total of 160 patients experienced 224 febrile neutropenic events. The risk of febrile neutropenia was significantly associated with age > or = 65 years (p = 0.001), cardiovascular disease (p = 0.020), renal disease (p = 0.006), baseline hemoglobin < 12 g/dl (p = 0.018), > 80% planned average relative dose intensity (ARDI; p = 0.018), and no prophylactic colony-stimulating factor (CSF) use (p = 0.046). First febrile neutropenic events occurred by day 14 of cycle 1 in one-half of patients experiencing febrile neutropenia. In multivariate analysis, the risk of febrile neutropenia remained significantly associated with age > or = 65 years (HR = 1.65, 95% CI: 1.18-2.32), renal disease (HR = 1.91. 95% CI: 1.10-3.30), cardiovascular disease (HR = 1.54, 95% CI: 1.02-2.33), baseline hemoglobin < 12 g/dl (HR = 1.44, 95% CI: 1.04-2.00), > 80% planned CHOP ARDI (HR = 2.41, 95% CI: 1.30-4.47), and no CSF prophylaxis (HR = 2.13, 95% CI: 1.20-3.76). Such a model may permit the identification of patients at greatest risk of febrile neutropenia and, therefore, candidates for the selective prophylactic use of the hematopoietic growth factors.

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Published In

Leuk Lymphoma

DOI

ISSN

1042-8194

Publication Date

December 2003

Volume

44

Issue

12

Start / End Page

2069 / 2076

Location

United States

Related Subject Headings

  • Vincristine
  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Risk
  • Retrospective Studies
  • Prednisolone
  • Neutropenia
  • Multivariate Analysis
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lyman, G. H., Morrison, V. A., Dale, D. C., Crawford, J., Delgado, D. J., Fridman, M., … ANC Study Group, . (2003). Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy. Leuk Lymphoma, 44(12), 2069–2076. https://doi.org/10.1080/1042819031000119262
Lyman, Gary H., Vicki A. Morrison, David C. Dale, Jeffrey Crawford, David J. Delgado, Moshe Fridman, Moshe OPPS Working Group, and Moshe ANC Study Group. “Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy.Leuk Lymphoma 44, no. 12 (December 2003): 2069–76. https://doi.org/10.1080/1042819031000119262.
Lyman GH, Morrison VA, Dale DC, Crawford J, Delgado DJ, Fridman M, et al. Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy. Leuk Lymphoma. 2003 Dec;44(12):2069–76.
Lyman, Gary H., et al. “Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy.Leuk Lymphoma, vol. 44, no. 12, Dec. 2003, pp. 2069–76. Pubmed, doi:10.1080/1042819031000119262.
Lyman GH, Morrison VA, Dale DC, Crawford J, Delgado DJ, Fridman M, OPPS Working Group, ANC Study Group. Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy. Leuk Lymphoma. 2003 Dec;44(12):2069–2076.

Published In

Leuk Lymphoma

DOI

ISSN

1042-8194

Publication Date

December 2003

Volume

44

Issue

12

Start / End Page

2069 / 2076

Location

United States

Related Subject Headings

  • Vincristine
  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Risk
  • Retrospective Studies
  • Prednisolone
  • Neutropenia
  • Multivariate Analysis
  • Middle Aged