Scholars@Duke
Journal cover image

Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma.

Journal articles  - Journal Article
McLaughlin, PW; Mancini, WR; Stetson, PL; Greenberg, HS; Nguyen, N; Seabury, H; Heidorn, DB; Lawrence, TS
Published in: Int J Radiat Oncol Biol Phys
July 15, 1993
Published version (DOI) Link to item

PURPOSE: To determine the potential advantage of combining halogenated pyrimidine radiosensitization and continuous low dose rate irradiation in human malignant glioma. METHODS AND MATERIALS: An established glioma line (U-251) was incubated with 5-bromo-2-doxyuridine (BrdUrd) at clinically achievable concentrations at three dose rates of interest--100 cGy/min (typical of external beam therapy), 43 cGy/hr (typical of temporary afterloaded implants), and 12 cGy/hr (typical of permanent implants). RESULTS: After exposure to 1 microM BrdUrd, the greatest enhancement ratio was seen at the 12 cGy/hr dose rate, implying a BrdUrd induced inverse dose rate effect independent of a G2M block. Under these conditions, the mean inactivation dose after 1 microM BrdUrd exposure was equivalent for 100 cGy/min and 12 cGy/hr. CONCLUSION: These results support the use of halopyrimidines as sensitizers of temporary afterloaded and permanent implants.

Duke Scholars

Heather Seabury McLean
Author Heather Seabury McLean Pediatrics, Hospital Medicine
Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Radiat Oncol Biol Phys

DOI

10.1016/0360-3016(93)90281-y

ISSN

0360-3016

Publication Date

July 15, 1993

Volume

26

Issue

4

Start / End Page

637 / 642

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Survival Rate
  • Radiotherapy Dosage
  • Radiation-Sensitizing Agents
  • Oncology & Carcinogenesis
  • In Vitro Techniques
  • Humans
  • Glioma
  • Dose-Response Relationship, Radiation
  • Bromodeoxyuridine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McLaughlin, P. W., Mancini, W. R., Stetson, P. L., Greenberg, H. S., Nguyen, N., Seabury, H., … Lawrence, T. S. (1993). Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma. Int J Radiat Oncol Biol Phys, 26(4), 637–642. https://doi.org/10.1016/0360-3016(93)90281-y
McLaughlin, P. W., W. R. Mancini, P. L. Stetson, H. S. Greenberg, N. Nguyen, H. Seabury, D. B. Heidorn, and T. S. Lawrence. “Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma.” Int J Radiat Oncol Biol Phys 26, no. 4 (July 15, 1993): 637–42. https://doi.org/10.1016/0360-3016(93)90281-y.
McLaughlin PW, Mancini WR, Stetson PL, Greenberg HS, Nguyen N, Seabury H, et al. Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma. Int J Radiat Oncol Biol Phys. 1993 Jul 15;26(4):637–42.
McLaughlin, P. W., et al. “Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma.” Int J Radiat Oncol Biol Phys, vol. 26, no. 4, July 1993, pp. 637–42. Pubmed, doi:10.1016/0360-3016(93)90281-y.
McLaughlin PW, Mancini WR, Stetson PL, Greenberg HS, Nguyen N, Seabury H, Heidorn DB, Lawrence TS. Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma. Int J Radiat Oncol Biol Phys. 1993 Jul 15;26(4):637–642.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

10.1016/0360-3016(93)90281-y

ISSN

0360-3016

Publication Date

July 15, 1993

Volume

26

Issue

4

Start / End Page

637 / 642

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Survival Rate
  • Radiotherapy Dosage
  • Radiation-Sensitizing Agents
  • Oncology & Carcinogenesis
  • In Vitro Techniques
  • Humans
  • Glioma
  • Dose-Response Relationship, Radiation
  • Bromodeoxyuridine