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The multiple causes of human SCID.

Publication ,  Journal Article
Buckley, RH
Published in: J Clin Invest
November 2004

SCID, a syndrome characterized by the absence of T cells and adaptive immunity, can result from mutations in multiple genes that encode components of the immune system. Three such components are cytokine receptor chains or signaling molecules, five are needed for antigen receptor development, one is adenosine deaminase--a purine salvage pathway enzyme, and the last is a phosphatase, CD45. In this issue of the JCI, a report describes how complete deficiency of the CD3epsilon chain of the T cell antigen receptor/CD3 complex causes human SCID.

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

November 2004

Volume

114

Issue

10

Start / End Page

1409 / 1411

Location

United States

Related Subject Headings

  • Severe Combined Immunodeficiency
  • Receptors, Cytokine
  • Receptors, Antigen, T-Cell
  • Receptor-CD3 Complex, Antigen, T-Cell
  • Protein Subunits
  • Pedigree
  • Mutation
  • Models, Biological
  • Leukocyte Common Antigens
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Buckley, R. H. (2004). The multiple causes of human SCID. J Clin Invest, 114(10), 1409–1411. https://doi.org/10.1172/JCI23571
Buckley, Rebecca H. “The multiple causes of human SCID.J Clin Invest 114, no. 10 (November 2004): 1409–11. https://doi.org/10.1172/JCI23571.
Buckley RH. The multiple causes of human SCID. J Clin Invest. 2004 Nov;114(10):1409–11.
Buckley, Rebecca H. “The multiple causes of human SCID.J Clin Invest, vol. 114, no. 10, Nov. 2004, pp. 1409–11. Pubmed, doi:10.1172/JCI23571.
Buckley RH. The multiple causes of human SCID. J Clin Invest. 2004 Nov;114(10):1409–1411.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

November 2004

Volume

114

Issue

10

Start / End Page

1409 / 1411

Location

United States

Related Subject Headings

  • Severe Combined Immunodeficiency
  • Receptors, Cytokine
  • Receptors, Antigen, T-Cell
  • Receptor-CD3 Complex, Antigen, T-Cell
  • Protein Subunits
  • Pedigree
  • Mutation
  • Models, Biological
  • Leukocyte Common Antigens
  • Immunology