The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.
Publication
, Journal Article
Speer, MC; Worley, G; Mackey, JF; Melvin, E; Oakes, WJ; George, TM
Published in: Neurogenetics
September 1997
Mutations in the gene for methylenetetrahydrofolate reductase (MTHFR) have been implicated as a risk factor in the formation of neural tube defects. We investigated this gene in a series of 65 sporadic American Caucasian patients with lumbosacral NTD and their unaffected parents, using both case-control design and assessment of linkage disequilibrium. We found no evidence to support mutations in MTHFR as a significant risk factor for NTD in this population.
Duke Scholars
Published In
Neurogenetics
DOI
ISSN
1364-6745
Publication Date
September 1997
Volume
1
Issue
2
Start / End Page
149 / 150
Location
United States
Related Subject Headings
- White People
- Temperature
- Risk Factors
- Oxidoreductases Acting on CH-NH Group Donors
- Neurology & Neurosurgery
- Neural Tube Defects
- Methylenetetrahydrofolate Reductase (NADPH2)
- Male
- Humans
- Genotype
Citation
APA
Chicago
ICMJE
MLA
NLM
Speer, M. C., Worley, G., Mackey, J. F., Melvin, E., Oakes, W. J., & George, T. M. (1997). The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group. Neurogenetics, 1(2), 149–150. https://doi.org/10.1007/s100480050022
Speer, M. C., G. Worley, J. F. Mackey, E. Melvin, W. J. Oakes, and T. M. George. “The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.” Neurogenetics 1, no. 2 (September 1997): 149–50. https://doi.org/10.1007/s100480050022.
Speer MC, Worley G, Mackey JF, Melvin E, Oakes WJ, George TM. The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group. Neurogenetics. 1997 Sep;1(2):149–50.
Speer, M. C., et al. “The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.” Neurogenetics, vol. 1, no. 2, Sept. 1997, pp. 149–50. Pubmed, doi:10.1007/s100480050022.
Speer MC, Worley G, Mackey JF, Melvin E, Oakes WJ, George TM. The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group. Neurogenetics. 1997 Sep;1(2):149–150.
Published In
Neurogenetics
DOI
ISSN
1364-6745
Publication Date
September 1997
Volume
1
Issue
2
Start / End Page
149 / 150
Location
United States
Related Subject Headings
- White People
- Temperature
- Risk Factors
- Oxidoreductases Acting on CH-NH Group Donors
- Neurology & Neurosurgery
- Neural Tube Defects
- Methylenetetrahydrofolate Reductase (NADPH2)
- Male
- Humans
- Genotype