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Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency.

Publication ,  Journal Article
Fleenor, D; Oden, J; Kelly, PA; Mohan, S; Alliouachene, S; Pende, M; Wentz, S; Kerr, J; Freemark, M
Published in: Endocrinology
January 2005

To delineate the roles of the lactogens and GH in the control of perinatal and postnatal growth, fat deposition, insulin production, and insulin action, we generated a novel mouse model that combines resistance to all lactogenic hormones with a severe deficiency of pituitary GH. The model was created by breeding PRL receptor (PRLR)-deficient (knockout) males with GH-deficient (little) females. In contrast to mice with isolated GH or PRLR deficiencies, double-mutant (lactogen-resistant and GH-deficient) mice on d 7 of life had growth failure and hypoglycemia. These findings suggest that lactogens and GH act in concert to facilitate weight gain and glucose homeostasis during the perinatal period. Plasma insulin and IGF-I and IGF-II concentrations were decreased in both GH-deficient and double-mutant neonates but were normal in PRLR-deficient mice. Body weights of the double mutants were reduced markedly during the first 3-4 months of age, and adults had striking reductions in femur length, plasma IGF-I and IGF binding protein-3 concentrations, and femoral bone mineral density. By age 6-12 months, however, the double-mutant mice developed obesity, hyperleptinemia, fasting hyperglycemia, relative hypoinsulinemia, insulin resistance, and glucose intolerance; males were affected to a greater degree than females. The combination of perinatal growth failure and late-onset obesity and insulin resistance suggests that the lactogen-resistant/GH-deficient mouse may serve as a model for the development of the metabolic syndrome.

Duke Scholars

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

January 2005

Volume

146

Issue

1

Start / End Page

103 / 112

Location

United States

Related Subject Headings

  • Weight Gain
  • Somatomedins
  • Receptors, Prolactin
  • Prolactin
  • Placental Lactogen
  • Osmolar Concentration
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
 

Citation

APA
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ICMJE
MLA
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Fleenor, D., Oden, J., Kelly, P. A., Mohan, S., Alliouachene, S., Pende, M., … Freemark, M. (2005). Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. Endocrinology, 146(1), 103–112. https://doi.org/10.1210/en.2004-0744
Fleenor, Donald, Jon Oden, Paul A. Kelly, Subburaman Mohan, Samira Alliouachene, Mario Pende, Sabrina Wentz, Jennifer Kerr, and Michael Freemark. “Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency.Endocrinology 146, no. 1 (January 2005): 103–12. https://doi.org/10.1210/en.2004-0744.
Fleenor, Donald, et al. “Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency.Endocrinology, vol. 146, no. 1, Jan. 2005, pp. 103–12. Pubmed, doi:10.1210/en.2004-0744.
Fleenor D, Oden J, Kelly PA, Mohan S, Alliouachene S, Pende M, Wentz S, Kerr J, Freemark M. Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. Endocrinology. 2005 Jan;146(1):103–112.
Journal cover image

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

January 2005

Volume

146

Issue

1

Start / End Page

103 / 112

Location

United States

Related Subject Headings

  • Weight Gain
  • Somatomedins
  • Receptors, Prolactin
  • Prolactin
  • Placental Lactogen
  • Osmolar Concentration
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male