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Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience.

Publication ,  Journal Article
Adamkiewicz, TV; Szabolcs, P; Haight, A; Baker, KS; Staba, S; Kedar, A; Chiang, KY; Krishnamurti, L; Boyer, MW; Kurtzberg, J; Wagner, JE ...
Published in: Pediatr Transplant
September 2007

UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n=5; 5/6 n=2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

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Published In

Pediatr Transplant

DOI

ISSN

1397-3142

Publication Date

September 2007

Volume

11

Issue

6

Start / End Page

641 / 644

Location

Denmark

Related Subject Headings

  • Surgery
  • Male
  • Humans
  • Fetal Blood
  • Female
  • Child, Preschool
  • Child
  • Anemia, Sickle Cell
  • Adolescent
  • 3213 Paediatrics
 

Citation

APA
Chicago
ICMJE
MLA
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Adamkiewicz, T. V., Szabolcs, P., Haight, A., Baker, K. S., Staba, S., Kedar, A., … Yeager, A. M. (2007). Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience. Pediatr Transplant, 11(6), 641–644. https://doi.org/10.1111/j.1399-3046.2007.00725.x
Adamkiewicz, Tom V., Paul Szabolcs, Ann Haight, K Scott Baker, Susan Staba, Amos Kedar, K. Y. Chiang, et al. “Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience.Pediatr Transplant 11, no. 6 (September 2007): 641–44. https://doi.org/10.1111/j.1399-3046.2007.00725.x.
Adamkiewicz TV, Szabolcs P, Haight A, Baker KS, Staba S, Kedar A, et al. Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience. Pediatr Transplant. 2007 Sep;11(6):641–4.
Adamkiewicz, Tom V., et al. “Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience.Pediatr Transplant, vol. 11, no. 6, Sept. 2007, pp. 641–44. Pubmed, doi:10.1111/j.1399-3046.2007.00725.x.
Adamkiewicz TV, Szabolcs P, Haight A, Baker KS, Staba S, Kedar A, Chiang KY, Krishnamurti L, Boyer MW, Kurtzberg J, Wagner JE, Wingard JR, Yeager AM. Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience. Pediatr Transplant. 2007 Sep;11(6):641–644.
Journal cover image

Published In

Pediatr Transplant

DOI

ISSN

1397-3142

Publication Date

September 2007

Volume

11

Issue

6

Start / End Page

641 / 644

Location

Denmark

Related Subject Headings

  • Surgery
  • Male
  • Humans
  • Fetal Blood
  • Female
  • Child, Preschool
  • Child
  • Anemia, Sickle Cell
  • Adolescent
  • 3213 Paediatrics