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Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth.

Publication ,  Journal Article
Murtha, AP; Nieves, A; Hauser, ER; Swamy, GK; Yonish, BA; Sinclair, TR; Heine, RP
Published in: Am J Obstet Gynecol
November 2006

OBJECTIVE: This study was undertaken to determine whether the interleukin-1 receptor antagonist (IL-1RN) variable number tandem repeat polymorphism is associated with preterm birth. STUDY DESIGN: A case-control study was performed. Cases (n = 95) delivered before 37 weeks after preterm labor (PTL) or preterm premature rupture of membranes (PPROM) and controls (n = 105) delivered after 37 weeks. Maternal DNA was genotyped by polymerase chain reaction for a length polymorphism in intron 2 of the IL-1RN gene. RESULTS: There was no significant difference in maternal age, ethnicity, insurance status, or parity between groups. Allele and genotype frequencies did not differ significantly from that expected under Hardy-Weinberg equilibrium (P = .59) in the total group as well as study groups. Of the 95 cases, 26.8% had at least 1 copy of allele 2 present compared with 12.4% in the control group (P < .0004). CONCLUSION: Maternal carriage of at least 1 copy of the IL-1RN allele 2 appears to be associated with increased risk of preterm birth.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

November 2006

Volume

195

Issue

5

Start / End Page

1249 / 1253

Location

United States

Related Subject Headings

  • Tandem Repeat Sequences
  • Premature Birth
  • Pregnancy
  • Polymorphism, Genetic
  • Obstetrics & Reproductive Medicine
  • Introns
  • Interleukin 1 Receptor Antagonist Protein
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Murtha, A. P., Nieves, A., Hauser, E. R., Swamy, G. K., Yonish, B. A., Sinclair, T. R., & Heine, R. P. (2006). Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth. Am J Obstet Gynecol, 195(5), 1249–1253. https://doi.org/10.1016/j.ajog.2006.09.002
Murtha, Amy P., Angel Nieves, Elizabeth R. Hauser, Geeta K. Swamy, Bryan A. Yonish, Tammy R. Sinclair, and R Phillips Heine. “Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth.Am J Obstet Gynecol 195, no. 5 (November 2006): 1249–53. https://doi.org/10.1016/j.ajog.2006.09.002.
Murtha AP, Nieves A, Hauser ER, Swamy GK, Yonish BA, Sinclair TR, et al. Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth. Am J Obstet Gynecol. 2006 Nov;195(5):1249–53.
Murtha, Amy P., et al. “Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth.Am J Obstet Gynecol, vol. 195, no. 5, Nov. 2006, pp. 1249–53. Pubmed, doi:10.1016/j.ajog.2006.09.002.
Murtha AP, Nieves A, Hauser ER, Swamy GK, Yonish BA, Sinclair TR, Heine RP. Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth. Am J Obstet Gynecol. 2006 Nov;195(5):1249–1253.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

November 2006

Volume

195

Issue

5

Start / End Page

1249 / 1253

Location

United States

Related Subject Headings

  • Tandem Repeat Sequences
  • Premature Birth
  • Pregnancy
  • Polymorphism, Genetic
  • Obstetrics & Reproductive Medicine
  • Introns
  • Interleukin 1 Receptor Antagonist Protein
  • Humans
  • Genotype
  • Genetic Predisposition to Disease