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PIN1, the cell cycle and cancer.

Publication ,  Journal Article
Yeh, ES; Means, AR
Published in: Nat Rev Cancer
May 2007
Published version (DOI) Link to item

PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and so affect protein function and/or stability. PIN1 regulates a number of proteins important for cell-cycle progression and, based on gain- and loss-of-function studies, is presumed to operate as a molecular timer of this important process. Therefore, it seems logical that alterations in the level of PIN1 can influence hyperproliferative diseases such as cancer. However, the precise role of PIN1 in cancer remains controversial.

Duke Scholars

Anthony Ross Means
Author Anthony Ross Means Pharmacology & Cancer Biology

Published In

Nat Rev Cancer

DOI

10.1038/nrc2107

ISSN

1474-175X

Publication Date

May 2007

Volume

7

Issue

5

Start / End Page

381 / 388

Location

England

Related Subject Headings

  • Tumor Suppressor Proteins
  • Peptidylprolyl Isomerase
  • Oncology & Carcinogenesis
  • Neoplasms
  • NIMA-Interacting Peptidylprolyl Isomerase
  • Models, Biological
  • Humans
  • Cyclin E
  • Cell Cycle Proteins
  • Cell Cycle
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yeh, E. S., & Means, A. R. (2007). PIN1, the cell cycle and cancer. Nat Rev Cancer, 7(5), 381–388. https://doi.org/10.1038/nrc2107
Yeh, Elizabeth S., and Anthony R. Means. “PIN1, the cell cycle and cancer.” Nat Rev Cancer 7, no. 5 (May 2007): 381–88. https://doi.org/10.1038/nrc2107.
Yeh ES, Means AR. PIN1, the cell cycle and cancer. Nat Rev Cancer. 2007 May;7(5):381–8.
Yeh, Elizabeth S., and Anthony R. Means. “PIN1, the cell cycle and cancer.” Nat Rev Cancer, vol. 7, no. 5, May 2007, pp. 381–88. Pubmed, doi:10.1038/nrc2107.
Yeh ES, Means AR. PIN1, the cell cycle and cancer. Nat Rev Cancer. 2007 May;7(5):381–388.

Published In

Nat Rev Cancer

DOI

10.1038/nrc2107

ISSN

1474-175X

Publication Date

May 2007

Volume

7

Issue

5

Start / End Page

381 / 388

Location

England

Related Subject Headings

  • Tumor Suppressor Proteins
  • Peptidylprolyl Isomerase
  • Oncology & Carcinogenesis
  • Neoplasms
  • NIMA-Interacting Peptidylprolyl Isomerase
  • Models, Biological
  • Humans
  • Cyclin E
  • Cell Cycle Proteins
  • Cell Cycle