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Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers.

Publication ,  Journal Article
Browndyke, JN; Tucker, KA; Woods, SP; Beauvals, J; Cohen, RA; Gottschalk, PC; Kosten, TR
Published in: J Neuroimaging
April 2004

BACKGROUND AND PURPOSE: Cerebral perfusion abnormalities and neuropsychological impairment are common sequelae of chronic cocaine abuse. While perfusion abnormalities have been shown to relate to cognitive deficits in this substance abuse population, the relationship between cognitive performance and the magnitude of perfusion abnormality has yet to be fully determined. METHODS: Thirty-seven abstinent cocaine abusers and 13 normal controls were administered resting 99m-Tc-HMPAO single photon emission computed tomography (SPECT) scans followed by a neuropsychological assessment battery tapping executive skills, attention, memory, and motor performance. Statistical parametric mapping (SPM99) techniques were used to analyze the SPECT data to detect significant regional perfusion abnormalities in the cocaine group relative to normal controls, and resulting abnormal SPECT counts were employed for comparison with the assessment measures to examine the relationship between cocaine-induced perfusion abnormalities and cognitive performance. RESULTS: SPECT data analysis revealed significant regional perfusion abnormalities in the cocaine abuse sample relative to controls and significant differences in neuropsychological functioning on measures of executive functioning, complex attention, memory, and manual dexterity. For chronic cocaine abusers, however, within-group comparisons of the magnitude of abnormal perfusion and neuropsychological performance were largely nonsignificant, with the exception of complex attention and motor speed. CONCLUSIONS: Perfusion abnormalities and neuropsychological impairments readily distinguished cocaine abusers from normal controls. However, when the magnitude of cocaine-induced perfusion abnormalities is examined in relation to cognitive performance, motor speed and complex attention appear to be the best behaviorial indicants of the severity of perfusion dysfunction within this substance abuse population.

Duke Scholars

Published In

J Neuroimaging

ISSN

1051-2284

Publication Date

April 2004

Volume

14

Issue

2

Start / End Page

162 / 169

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Technetium Tc 99m Exametazime
  • Substance Withdrawal Syndrome
  • Reproducibility of Results
  • Regional Blood Flow
  • Reference Values
  • Psychometrics
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Browndyke, J. N., Tucker, K. A., Woods, S. P., Beauvals, J., Cohen, R. A., Gottschalk, P. C., & Kosten, T. R. (2004). Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers. J Neuroimaging, 14(2), 162–169.
Browndyke, Jeffrey N., Karen A. Tucker, Steven P. Woods, John Beauvals, Ronald A. Cohen, P. C. Gottschalk, and Thomas R. Kosten. “Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers.J Neuroimaging 14, no. 2 (April 2004): 162–69.
Browndyke JN, Tucker KA, Woods SP, Beauvals J, Cohen RA, Gottschalk PC, et al. Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers. J Neuroimaging. 2004 Apr;14(2):162–9.
Browndyke, Jeffrey N., et al. “Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers.J Neuroimaging, vol. 14, no. 2, Apr. 2004, pp. 162–69.
Browndyke JN, Tucker KA, Woods SP, Beauvals J, Cohen RA, Gottschalk PC, Kosten TR. Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers. J Neuroimaging. 2004 Apr;14(2):162–169.
Journal cover image

Published In

J Neuroimaging

ISSN

1051-2284

Publication Date

April 2004

Volume

14

Issue

2

Start / End Page

162 / 169

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Technetium Tc 99m Exametazime
  • Substance Withdrawal Syndrome
  • Reproducibility of Results
  • Regional Blood Flow
  • Reference Values
  • Psychometrics
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Male