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Age-dependent reduction of amygdala volume in bipolar disorder.

Publication ,  Journal Article
Doty, TJ; Payne, ME; Steffens, DC; Beyer, JL; Krishnan, KRR; LaBar, KS
Published in: Psychiatry Res
May 30, 2008

The amygdala is hypothesized to play a critical role in mood regulation, yet its involvement in bipolar disorder remains unclear. The aim of the present study was to compare measurements of amygdala volumes in a relatively large sample of bipolar disorder patients and healthy controls ranging in age from 18 to 49 years. Subjects comprised 54 adult patients meeting DSM-IV criteria for bipolar disorder and 41 healthy controls matched for age, sex, and education. Magnetic resonance imaging (1.5 T) was performed to obtain volumetric measurements of the amygdala using a manual region-of-interest tracing method with software that allowed simultaneous visualization of the amygdala in three orthogonal planes. The anterior head of the hippocampus was removed in the sagittal plane prior to amygdala volumetry measurement. Multiple regression analysis was computed on amygdala volume measurements as a function of diagnosis, age, sex, and cerebral volume. Bipolar patients showed an age-related reduction of amygdala volume, but controls did not. Among bipolar subjects, amygdala volume was unrelated to medication history. There were no significant hemispheric or sex interactions with the main effects. Results support a role for amygdala dysfunction in bipolar disorder which appears most robustly in older relative to younger adult patients. Differential aging effects in bipolar disorder may compromise amygdala integrity and contribute to mood dysregulation.

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Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

May 30, 2008

Volume

163

Issue

1

Start / End Page

84 / 94

Location

Ireland

Related Subject Headings

  • Reference Values
  • Psychiatry
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Bipolar Disorder
  • Atrophy
 

Citation

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ICMJE
MLA
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Doty, T. J., Payne, M. E., Steffens, D. C., Beyer, J. L., Krishnan, K. R. R., & LaBar, K. S. (2008). Age-dependent reduction of amygdala volume in bipolar disorder. Psychiatry Res, 163(1), 84–94. https://doi.org/10.1016/j.pscychresns.2007.08.003
Doty, Tracy J., Martha E. Payne, David C. Steffens, John L. Beyer, K Ranga R. Krishnan, and Kevin S. LaBar. “Age-dependent reduction of amygdala volume in bipolar disorder.Psychiatry Res 163, no. 1 (May 30, 2008): 84–94. https://doi.org/10.1016/j.pscychresns.2007.08.003.
Doty TJ, Payne ME, Steffens DC, Beyer JL, Krishnan KRR, LaBar KS. Age-dependent reduction of amygdala volume in bipolar disorder. Psychiatry Res. 2008 May 30;163(1):84–94.
Doty, Tracy J., et al. “Age-dependent reduction of amygdala volume in bipolar disorder.Psychiatry Res, vol. 163, no. 1, May 2008, pp. 84–94. Pubmed, doi:10.1016/j.pscychresns.2007.08.003.
Doty TJ, Payne ME, Steffens DC, Beyer JL, Krishnan KRR, LaBar KS. Age-dependent reduction of amygdala volume in bipolar disorder. Psychiatry Res. 2008 May 30;163(1):84–94.
Journal cover image

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

May 30, 2008

Volume

163

Issue

1

Start / End Page

84 / 94

Location

Ireland

Related Subject Headings

  • Reference Values
  • Psychiatry
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Bipolar Disorder
  • Atrophy