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Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats.

Publication ,  Journal Article
Huwe, JK; Hakk, H; Smith, DJ; Diliberto, JJ; Richardson, V; Stapleton, HM; Birnbaum, LS
Published in: Environmental science & technology
April 2008

Household dust has been implicated as a major source of polybrominated diphenyl ether (PBDE) exposure in humans. This finding has important implications for young children, who tend to ingest more dust than adults and may be more susceptible to some of the putative developmental effects of PBDEs. Absorption parameters of PBDEs from ingested dust are unknown; therefore, the objectives of this study were to determine and to compare the uptake of PBDEs from either household dust (NIST Standard Reference Material 2585) or a corn oil solution. Male rats were administered dust or corn oil doses at 1 or 6 microg of PBDEs kg(-1) body wt in the diet for 21 days (n = 4 rats per group). The concentrations of 15 PBDEs were measured in adipose tissue and liver from each treatment group and showed that bioconcentration was congener dependent, but for the majority of congeners, the concentrations did not differ with either dose level or dose vehicle. Hepatic Cyp2b1 and 2b2 mRNA expression increased in rats receiving the higher PBDE doses, suggesting potential effects on metabolic activity. Retention of PBDEs in tissues ranged from <5% of the dose for BDE-209 to 70% for BDEs-47, 100, and 153 but generally did not differ between the high dust and high oil treatment groups. Excretion via the feces was significantly lower in the high oil dosed rats suggesting differences in absorption, excretion, and/or metabolism. The present study shows that PBDEs in dust are readily bioavailable and are biologically active, as indicated by increased transcription of hepatic enzymes.

Duke Scholars

Published In

Environmental science & technology

DOI

EISSN

1520-5851

ISSN

0013-936X

Publication Date

April 2008

Volume

42

Issue

7

Start / End Page

2694 / 2700

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Polybrominated Biphenyls
  • Oils
  • Male
  • Ethers
  • Environmental Sciences
  • Dust
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huwe, J. K., Hakk, H., Smith, D. J., Diliberto, J. J., Richardson, V., Stapleton, H. M., & Birnbaum, L. S. (2008). Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats. Environmental Science & Technology, 42(7), 2694–2700. https://doi.org/10.1021/es702644k
Huwe, Janice K., Heldur Hakk, David J. Smith, Janet J. Diliberto, Vicki Richardson, Heather M. Stapleton, and Linda S. Birnbaum. “Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats.Environmental Science & Technology 42, no. 7 (April 2008): 2694–2700. https://doi.org/10.1021/es702644k.
Huwe JK, Hakk H, Smith DJ, Diliberto JJ, Richardson V, Stapleton HM, et al. Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats. Environmental science & technology. 2008 Apr;42(7):2694–700.
Huwe, Janice K., et al. “Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats.Environmental Science & Technology, vol. 42, no. 7, Apr. 2008, pp. 2694–700. Epmc, doi:10.1021/es702644k.
Huwe JK, Hakk H, Smith DJ, Diliberto JJ, Richardson V, Stapleton HM, Birnbaum LS. Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats. Environmental science & technology. 2008 Apr;42(7):2694–2700.
Journal cover image

Published In

Environmental science & technology

DOI

EISSN

1520-5851

ISSN

0013-936X

Publication Date

April 2008

Volume

42

Issue

7

Start / End Page

2694 / 2700

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Polybrominated Biphenyls
  • Oils
  • Male
  • Ethers
  • Environmental Sciences
  • Dust
  • Animals