Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.
Publication
, Journal Article
Gooden, DM; Schmidt, DMZ; Pollock, JA; Kabadi, AM; McCafferty, DG
Published in: Bioorganic & medicinal chemistry letters
May 2008
A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.
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Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
May 2008
Volume
18
Issue
10
Start / End Page
3047 / 3051
Related Subject Headings
- Tranylcypromine
- Structure-Activity Relationship
- Oxidoreductases, N-Demethylating
- Monoamine Oxidase
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Kinetics
- Humans
- Histones
- Histone Demethylases
Citation
APA
Chicago
ICMJE
MLA
NLM
Gooden, D. M., Schmidt, D. M. Z., Pollock, J. A., Kabadi, A. M., & McCafferty, D. G. (2008). Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. Bioorganic & Medicinal Chemistry Letters, 18(10), 3047–3051. https://doi.org/10.1016/j.bmcl.2008.01.003
Gooden, David M., Dawn M. Z. Schmidt, Julie A. Pollock, Ami M. Kabadi, and Dewey G. McCafferty. “Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.” Bioorganic & Medicinal Chemistry Letters 18, no. 10 (May 2008): 3047–51. https://doi.org/10.1016/j.bmcl.2008.01.003.
Gooden DM, Schmidt DMZ, Pollock JA, Kabadi AM, McCafferty DG. Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. Bioorganic & medicinal chemistry letters. 2008 May;18(10):3047–51.
Gooden, David M., et al. “Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.” Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 10, May 2008, pp. 3047–51. Epmc, doi:10.1016/j.bmcl.2008.01.003.
Gooden DM, Schmidt DMZ, Pollock JA, Kabadi AM, McCafferty DG. Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. Bioorganic & medicinal chemistry letters. 2008 May;18(10):3047–3051.
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
May 2008
Volume
18
Issue
10
Start / End Page
3047 / 3051
Related Subject Headings
- Tranylcypromine
- Structure-Activity Relationship
- Oxidoreductases, N-Demethylating
- Monoamine Oxidase
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Kinetics
- Humans
- Histones
- Histone Demethylases