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Proton-beam irradiated epithelioid cell melanoma of the ciliary body.

Publication ,  Journal Article
Zinn, KM; Stein/Pokorny, K; Jakobiec, FA; Friedman, AH; Gragoudas, ES; Ritch, R
Published in: Ophthalmology
December 1981

A malignant ciliary body melanoma received proton-beam irradiation. After an apparent failure of the tumor to respond, the eye was enucleated. A predominantly epithelioid cell tumor appeared viable by light microscopy, and a low degree of mitotic activity persisted, despite therapy. The tumor cells, however, displayed degenerative changes ultrastructurally, presumably results of the radiotherapy. These consisted of numerous cytoskeletal filaments, lipid vacuoles, prominent phagolysosomes, and nuclear convolutions and fragmentations. The mitochondria were fewer in number in the present tumor than typically encountered in epithelioid cells. A rare leptomeric structure was discovered, probably an organizational modification of the cytoplasmic filaments. The tumor's capillaries showed radiation-induced changes in terms of thickened basement membranes and perivascular fibrin deposition. The foregoing features are indicative of cellular and metabolic injury from the radiotherapy, but these were evidently not sufficiently injurious to sterilize the tumor.

Duke Scholars

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

December 1981

Volume

88

Issue

12

Start / End Page

1315 / 1321

Location

United States

Related Subject Headings

  • Uveal Neoplasms
  • Protons
  • Particle Accelerators
  • Ophthalmology & Optometry
  • Melanoma
  • Male
  • Humans
  • Ciliary Body
  • Adult
  • 3212 Ophthalmology and optometry
 

Citation

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Zinn, K. M., Stein/Pokorny, K., Jakobiec, F. A., Friedman, A. H., Gragoudas, E. S., & Ritch, R. (1981). Proton-beam irradiated epithelioid cell melanoma of the ciliary body. Ophthalmology, 88(12), 1315–1321. https://doi.org/10.1016/s0161-6420(81)34883-0
Zinn, K. M., K. Stein/Pokorny, F. A. Jakobiec, A. H. Friedman, E. S. Gragoudas, and R. Ritch. “Proton-beam irradiated epithelioid cell melanoma of the ciliary body.Ophthalmology 88, no. 12 (December 1981): 1315–21. https://doi.org/10.1016/s0161-6420(81)34883-0.
Zinn KM, Stein/Pokorny K, Jakobiec FA, Friedman AH, Gragoudas ES, Ritch R. Proton-beam irradiated epithelioid cell melanoma of the ciliary body. Ophthalmology. 1981 Dec;88(12):1315–21.
Zinn, K. M., et al. “Proton-beam irradiated epithelioid cell melanoma of the ciliary body.Ophthalmology, vol. 88, no. 12, Dec. 1981, pp. 1315–21. Pubmed, doi:10.1016/s0161-6420(81)34883-0.
Zinn KM, Stein/Pokorny K, Jakobiec FA, Friedman AH, Gragoudas ES, Ritch R. Proton-beam irradiated epithelioid cell melanoma of the ciliary body. Ophthalmology. 1981 Dec;88(12):1315–1321.
Journal cover image

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

December 1981

Volume

88

Issue

12

Start / End Page

1315 / 1321

Location

United States

Related Subject Headings

  • Uveal Neoplasms
  • Protons
  • Particle Accelerators
  • Ophthalmology & Optometry
  • Melanoma
  • Male
  • Humans
  • Ciliary Body
  • Adult
  • 3212 Ophthalmology and optometry