Skip to main content

Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir).

Publication ,  Journal Article
Teich, SA; Castle, J; Friedman, AH; Siroty, W; Orellana, J; Schmitterer, M
Published in: Br J Ophthalmol
April 1988

The eyes of an AIDS patient with cytomegalovirus (CMV) retinitis and pneumonitis who died while receiving maintenance therapy with the antiviral agent 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir) were obtained for pathological examination. While under treatment the patient had significant improvement but not complete regression of retinitis. Electron microscopic and immunofluorescent techniques revealed cytomegalovirus particles in the retina, sclera, iris, and ciliary body. These findings are consistent with a virostatic type of inhibition of CMV by this agent. They also suggest that CMV involvement in the eye and other organs may be more widespread than is clinically apparent in AIDS patients.

Duke Scholars

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

April 1988

Volume

72

Issue

4

Start / End Page

293 / 298

Location

England

Related Subject Headings

  • Retinitis
  • Retina
  • Ophthalmology & Optometry
  • Male
  • Iris
  • Humans
  • Ganciclovir
  • Eye
  • Cytomegalovirus Infections
  • Cytomegalovirus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Teich, S. A., Castle, J., Friedman, A. H., Siroty, W., Orellana, J., & Schmitterer, M. (1988). Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir). Br J Ophthalmol, 72(4), 293–298. https://doi.org/10.1136/bjo.72.4.293
Teich, S. A., J. Castle, A. H. Friedman, W. Siroty, J. Orellana, and M. Schmitterer. “Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir).Br J Ophthalmol 72, no. 4 (April 1988): 293–98. https://doi.org/10.1136/bjo.72.4.293.
Teich SA, Castle J, Friedman AH, Siroty W, Orellana J, Schmitterer M. Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir). Br J Ophthalmol. 1988 Apr;72(4):293–8.
Teich, S. A., et al. “Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir).Br J Ophthalmol, vol. 72, no. 4, Apr. 1988, pp. 293–98. Pubmed, doi:10.1136/bjo.72.4.293.
Teich SA, Castle J, Friedman AH, Siroty W, Orellana J, Schmitterer M. Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir). Br J Ophthalmol. 1988 Apr;72(4):293–298.

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

April 1988

Volume

72

Issue

4

Start / End Page

293 / 298

Location

England

Related Subject Headings

  • Retinitis
  • Retina
  • Ophthalmology & Optometry
  • Male
  • Iris
  • Humans
  • Ganciclovir
  • Eye
  • Cytomegalovirus Infections
  • Cytomegalovirus