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Sclero-cornea and defective mesodermal migration.

Publication ,  Journal Article
Friedman, AH; Weingeist, S; Brackup, A; Marinoff, G
Published in: Br J Ophthalmol
November 1975

A 5-month-old boy with bilateral sclero-cornea, multiple systemic abnormalities, and normal karyotype had his left eye removed after corneal perforation. Histopathological examination of the enucleated eye revealed an irregular corneal epithelium, absent Bowman's membrane, thickened and vascularized stromal lamellae, absent Descemet's membrane and endothelium, no angle structures, hypoplasia of the iris and ciliary body, and total kerato-iridic adhesions. A profound defect in embryogenesis due to defective mesodermal migration during the earliest phase of mesoderm differentiation is postulated as the causative factor in this case.

Duke Scholars

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

November 1975

Volume

59

Issue

11

Start / End Page

683 / 687

Location

England

Related Subject Headings

  • Sclerosis
  • Retina
  • Ophthalmology & Optometry
  • Mesoderm
  • Male
  • Iris
  • Infant
  • Humans
  • Female
  • Descemet Membrane
 

Citation

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MLA
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Friedman, A. H., Weingeist, S., Brackup, A., & Marinoff, G. (1975). Sclero-cornea and defective mesodermal migration. Br J Ophthalmol, 59(11), 683–687. https://doi.org/10.1136/bjo.59.11.683
Friedman, A. H., S. Weingeist, A. Brackup, and G. Marinoff. “Sclero-cornea and defective mesodermal migration.Br J Ophthalmol 59, no. 11 (November 1975): 683–87. https://doi.org/10.1136/bjo.59.11.683.
Friedman AH, Weingeist S, Brackup A, Marinoff G. Sclero-cornea and defective mesodermal migration. Br J Ophthalmol. 1975 Nov;59(11):683–7.
Friedman, A. H., et al. “Sclero-cornea and defective mesodermal migration.Br J Ophthalmol, vol. 59, no. 11, Nov. 1975, pp. 683–87. Pubmed, doi:10.1136/bjo.59.11.683.
Friedman AH, Weingeist S, Brackup A, Marinoff G. Sclero-cornea and defective mesodermal migration. Br J Ophthalmol. 1975 Nov;59(11):683–687.

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

November 1975

Volume

59

Issue

11

Start / End Page

683 / 687

Location

England

Related Subject Headings

  • Sclerosis
  • Retina
  • Ophthalmology & Optometry
  • Mesoderm
  • Male
  • Iris
  • Infant
  • Humans
  • Female
  • Descemet Membrane