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Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.

Publication ,  Journal Article
Cisse, B; Caton, ML; Lehner, M; Maeda, T; Scheu, S; Locksley, R; Holmberg, D; Zweier, C; den Hollander, NS; Kant, SG; Holter, W; Rauch, A ...
Published in: Cell
October 3, 2008

Plasmacytoid dendritic cells (PDCs) represent a unique immune cell type specialized in type I interferon (IFN) secretion in response to viral nucleic acids. The molecular control of PDC lineage specification has been poorly understood. We report that basic helix-loop-helix transcription factor (E protein) E2-2/Tcf4 is preferentially expressed in murine and human PDCs. Constitutive or inducible deletion of murine E2-2 blocked the development of PDCs but not of other lineages and abolished IFN response to unmethylated DNA. Moreover, E2-2 haploinsufficiency in mice and in human Pitt-Hopkins syndrome patients was associated with aberrant expression profile and impaired IFN response of the PDC. E2-2 directly activated multiple PDC-enriched genes, including transcription factors involved in PDC development (SpiB, Irf8) and function (Irf7). These results identify E2-2 as a specific transcriptional regulator of the PDC lineage in mice and humans and reveal a key function of E proteins in the innate immune system.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

October 3, 2008

Volume

135

Issue

1

Start / End Page

37 / 48

Location

United States

Related Subject Headings

  • Transcription Factors
  • Transcription Factor 7-Like 2 Protein
  • Transcription Factor 4
  • TCF Transcription Factors
  • Syndrome
  • Nerve Tissue Proteins
  • Mice
  • Interferons
  • Intellectual Disability
  • Immunity, Innate
 

Citation

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Cisse, B., Caton, M. L., Lehner, M., Maeda, T., Scheu, S., Locksley, R., … Reizis, B. (2008). Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell, 135(1), 37–48. https://doi.org/10.1016/j.cell.2008.09.016
Cisse, Babacar, Michele L. Caton, Manfred Lehner, Takahiro Maeda, Stefanie Scheu, Richard Locksley, Dan Holmberg, et al. “Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.Cell 135, no. 1 (October 3, 2008): 37–48. https://doi.org/10.1016/j.cell.2008.09.016.
Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, et al. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 2008 Oct 3;135(1):37–48.
Cisse, Babacar, et al. “Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.Cell, vol. 135, no. 1, Oct. 2008, pp. 37–48. Pubmed, doi:10.1016/j.cell.2008.09.016.
Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 2008 Oct 3;135(1):37–48.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

October 3, 2008

Volume

135

Issue

1

Start / End Page

37 / 48

Location

United States

Related Subject Headings

  • Transcription Factors
  • Transcription Factor 7-Like 2 Protein
  • Transcription Factor 4
  • TCF Transcription Factors
  • Syndrome
  • Nerve Tissue Proteins
  • Mice
  • Interferons
  • Intellectual Disability
  • Immunity, Innate