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Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.

Publication ,  Journal Article
Meintjes, G; Lawn, SD; Scano, F; Maartens, G; French, MA; Worodria, W; Elliott, JH; Murdoch, D; Wilkinson, RJ; Seyler, C; John, L; Reiss, P ...
Published in: Lancet Infect Dis
August 2008

The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions are not readily applicable in settings where laboratory resources are limited. As a result, existing studies on tuberculosis-associated IRIS have used a variety of non-standardised general case definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met in Kampala, Uganda, in November, 2006. At this meeting, consensus case definitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis-associated IRIS were derived, which can be used in high-income and resource-limited settings. It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data.

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Published In

Lancet Infect Dis

DOI

ISSN

1473-3099

Publication Date

August 2008

Volume

8

Issue

8

Start / End Page

516 / 523

Location

United States

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Poverty
  • Middle Aged
  • Microbiology
  • Male
  • Immune Reconstitution Inflammatory Syndrome
  • Humans
  • Health Resources
  • HIV Infections
  • Antitubercular Agents
 

Citation

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Chicago
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MLA
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Meintjes, G., Lawn, S. D., Scano, F., Maartens, G., French, M. A., Worodria, W., … International Network for the Study of HIV-associated IRIS, . (2008). Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis, 8(8), 516–523. https://doi.org/10.1016/S1473-3099(08)70184-1
Meintjes, Graeme, Stephen D. Lawn, Fabio Scano, Gary Maartens, Martyn A. French, William Worodria, Julian H. Elliott, et al. “Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.Lancet Infect Dis 8, no. 8 (August 2008): 516–23. https://doi.org/10.1016/S1473-3099(08)70184-1.
Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, et al. Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis. 2008 Aug;8(8):516–23.
Meintjes, Graeme, et al. “Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.Lancet Infect Dis, vol. 8, no. 8, Aug. 2008, pp. 516–23. Pubmed, doi:10.1016/S1473-3099(08)70184-1.
Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, Elliott JH, Murdoch D, Wilkinson RJ, Seyler C, John L, van der Loeff MS, Reiss P, Lynen L, Janoff EN, Gilks C, Colebunders R, International Network for the Study of HIV-associated IRIS. Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis. 2008 Aug;8(8):516–523.
Journal cover image

Published In

Lancet Infect Dis

DOI

ISSN

1473-3099

Publication Date

August 2008

Volume

8

Issue

8

Start / End Page

516 / 523

Location

United States

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Poverty
  • Middle Aged
  • Microbiology
  • Male
  • Immune Reconstitution Inflammatory Syndrome
  • Humans
  • Health Resources
  • HIV Infections
  • Antitubercular Agents