ApoE genotype-specific inhibition of apoptosis.
Publication
, Journal Article
DeKroon, RM; Mihovilovic, M; Goodger, ZV; Robinette, JB; Sullivan, PM; Saunders, AM; Strittmatter, WJ
Published in: J Lipid Res
August 2003
Endothelial cell apoptosis can be initiated by withdrawing growth factors or serum, and is inhibited by HDL. Our results show that the total lipoprotein population from apolipoprotein E 4/4 (APOE4/4) sera is less anti-apoptotic than total lipoproteins from other APOE genotypes, as measured by caspase 3/7 activity. Moreover, APOE4/4 VLDL antagonizes the antiapoptotic activity of HDL by a mechanism requiring binding of apoE4 on VLDL particles to an LDL family receptor. This ability of APOE4/4 VLDL to inhibit the antiapoptotic effects of HDL presents a potential mechanism by which the expression of several diseases, including atherosclerosis, is enhanced by the APOE4 genotype.
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Published In
J Lipid Res
DOI
ISSN
0022-2275
Publication Date
August 2003
Volume
44
Issue
8
Start / End Page
1566 / 1573
Location
United States
Related Subject Headings
- Lysophospholipids
- Lipoproteins, VLDL
- Humans
- Genotype
- Cholesterol, HDL
- Cell Line
- Caspases
- Biochemistry & Molecular Biology
- Apoptosis
- Apolipoproteins E
Citation
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DeKroon, R. M., Mihovilovic, M., Goodger, Z. V., Robinette, J. B., Sullivan, P. M., Saunders, A. M., & Strittmatter, W. J. (2003). ApoE genotype-specific inhibition of apoptosis. J Lipid Res, 44(8), 1566–1573. https://doi.org/10.1194/jlr.M300097-JLR200
DeKroon, Robert M., Mirta Mihovilovic, Zoe V. Goodger, Jennifer B. Robinette, Patrick M. Sullivan, Ann M. Saunders, and Warren J. Strittmatter. “ApoE genotype-specific inhibition of apoptosis.” J Lipid Res 44, no. 8 (August 2003): 1566–73. https://doi.org/10.1194/jlr.M300097-JLR200.
DeKroon RM, Mihovilovic M, Goodger ZV, Robinette JB, Sullivan PM, Saunders AM, et al. ApoE genotype-specific inhibition of apoptosis. J Lipid Res. 2003 Aug;44(8):1566–73.
DeKroon, Robert M., et al. “ApoE genotype-specific inhibition of apoptosis.” J Lipid Res, vol. 44, no. 8, Aug. 2003, pp. 1566–73. Pubmed, doi:10.1194/jlr.M300097-JLR200.
DeKroon RM, Mihovilovic M, Goodger ZV, Robinette JB, Sullivan PM, Saunders AM, Strittmatter WJ. ApoE genotype-specific inhibition of apoptosis. J Lipid Res. 2003 Aug;44(8):1566–1573.
Published In
J Lipid Res
DOI
ISSN
0022-2275
Publication Date
August 2003
Volume
44
Issue
8
Start / End Page
1566 / 1573
Location
United States
Related Subject Headings
- Lysophospholipids
- Lipoproteins, VLDL
- Humans
- Genotype
- Cholesterol, HDL
- Cell Line
- Caspases
- Biochemistry & Molecular Biology
- Apoptosis
- Apolipoproteins E