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Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity.

Publication ,  Journal Article
Syu, WJ; Lee, WR; Du, B; Yu, QC; Essex, M; Lee, TH
Published in: J Virol
November 1991

All animal retroviruses whose nucleotide sequences have been determined contain two or three closely spaced cysteine residues in the extracellular domain of the env-encoded transmembrane protein. Using human immunodeficiency virus type 1 gp41 as a working model, the functional significance of these highly conserved cysteines was investigated. We report here that substituting the two conserved cysteine residues in this domain of gp41 with glycine residues resulted in the loss of viral infectivity, which could be attributed to severe impairment in the processing of gp160 precursor to gp120.

Duke Scholars

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

November 1991

Volume

65

Issue

11

Start / End Page

6349 / 6352

Location

United States

Related Subject Headings

  • Virology
  • Transfection
  • RNA-Directed DNA Polymerase
  • Proviruses
  • Protein Precursors
  • Oligodeoxyribonucleotides
  • Mutagenesis, Site-Directed
  • Molecular Sequence Data
  • HIV-1
  • HIV Reverse Transcriptase
 

Citation

APA
Chicago
ICMJE
MLA
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Syu, W. J., Lee, W. R., Du, B., Yu, Q. C., Essex, M., & Lee, T. H. (1991). Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity. J Virol, 65(11), 6349–6352. https://doi.org/10.1128/JVI.65.11.6349-6352.1991
Syu, W. J., W. R. Lee, B. Du, Q. C. Yu, M. Essex, and T. H. Lee. “Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity.J Virol 65, no. 11 (November 1991): 6349–52. https://doi.org/10.1128/JVI.65.11.6349-6352.1991.
Syu, W. J., et al. “Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity.J Virol, vol. 65, no. 11, Nov. 1991, pp. 6349–52. Pubmed, doi:10.1128/JVI.65.11.6349-6352.1991.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

November 1991

Volume

65

Issue

11

Start / End Page

6349 / 6352

Location

United States

Related Subject Headings

  • Virology
  • Transfection
  • RNA-Directed DNA Polymerase
  • Proviruses
  • Protein Precursors
  • Oligodeoxyribonucleotides
  • Mutagenesis, Site-Directed
  • Molecular Sequence Data
  • HIV-1
  • HIV Reverse Transcriptase