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Transformation of cell type in uveal melanomas: a quantitative histologic analysis.

Publication ,  Journal Article
Bechrakis, NE; Sehu, KW; Lee, WR; Damato, BE; Foerster, MH
Published in: Arch Ophthalmol
October 2000

OBJECTIVE: To describe the cytologic transformation and tumor progression in a series of uveal melanomas. METHODS: Fifteen cases of uveal melanoma, treated by primary transscleral local resection without primary adjuvant treatment, needed enucleation because of local tumor recurrence. Cytologic and cell morphometric features of the primary tumor and the intraocular recurrence were compared, with evaluation of the amounts of intermediate cells, epithelioid cells, mitotic figures, and nucleolar area. RESULTS: The cases were categorized into 2 groups, according to their cytologic characteristics. In the first group (5 cases), there was no cytopathological transformation in the recurrent tumor. The nucleolar area was increased in only 1 case. In the second group (10 cases), the recurrent tumors showed transformation into a more epithelioid cell type. In all but 1 case there was an increase in epithelioid cells in the tumor recurrence. The nucleolar area was increased significantly in all cases. The mean local recurrence interval in all cases was 15.3 months, with no difference between the groups. Death from metastases occurred in 7 cases in which the nucleolar area was 4.2 microm(2) in the primary tumor. CONCLUSIONS: These findings demonstrate that, in an individual tumor, the cytologic phenotype can change considerably even after a relatively short time, resulting in an increase in tumor-related mortality. CLINICAL RELEVANCE: Studies on the natural course of uveal melanoma have been very limited and based purely on observations on the progression of melanomas in terms of size and alteration of various clinical characteristics.

Duke Scholars

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

October 2000

Volume

118

Issue

10

Start / End Page

1406 / 1412

Location

United States

Related Subject Headings

  • Uveal Neoplasms
  • Phenotype
  • Ophthalmology & Optometry
  • Neoplasm Recurrence, Local
  • Mitotic Index
  • Middle Aged
  • Melanoma
  • Male
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bechrakis, N. E., Sehu, K. W., Lee, W. R., Damato, B. E., & Foerster, M. H. (2000). Transformation of cell type in uveal melanomas: a quantitative histologic analysis. Arch Ophthalmol, 118(10), 1406–1412. https://doi.org/10.1001/archopht.118.10.1406
Bechrakis, N. E., K. W. Sehu, W. R. Lee, B. E. Damato, and M. H. Foerster. “Transformation of cell type in uveal melanomas: a quantitative histologic analysis.Arch Ophthalmol 118, no. 10 (October 2000): 1406–12. https://doi.org/10.1001/archopht.118.10.1406.
Bechrakis NE, Sehu KW, Lee WR, Damato BE, Foerster MH. Transformation of cell type in uveal melanomas: a quantitative histologic analysis. Arch Ophthalmol. 2000 Oct;118(10):1406–12.
Bechrakis, N. E., et al. “Transformation of cell type in uveal melanomas: a quantitative histologic analysis.Arch Ophthalmol, vol. 118, no. 10, Oct. 2000, pp. 1406–12. Pubmed, doi:10.1001/archopht.118.10.1406.
Bechrakis NE, Sehu KW, Lee WR, Damato BE, Foerster MH. Transformation of cell type in uveal melanomas: a quantitative histologic analysis. Arch Ophthalmol. 2000 Oct;118(10):1406–1412.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

October 2000

Volume

118

Issue

10

Start / End Page

1406 / 1412

Location

United States

Related Subject Headings

  • Uveal Neoplasms
  • Phenotype
  • Ophthalmology & Optometry
  • Neoplasm Recurrence, Local
  • Mitotic Index
  • Middle Aged
  • Melanoma
  • Male
  • Humans
  • Female