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Aging affects the association between endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction in the Korean male population.

Publication ,  Journal Article
Park, JE; Lee, WH; Hwang, TH; Chu, JA; Kim, S; Choi, YH; Kim, JS; Kim, DK; Lee, SH; Hong, KP; Seo, JD; Lee, WR
Published in: Korean J Intern Med
January 2000

OBJECTIVES: The aging process affects responsiveness and other functions of endothelium and vascular smooth muscle cells, predisposing the old vessels to the development of atherosclerotic lesions. Endothelial nitric oxide synthase (ecNOS) gene polymorphisms were shown to affect the occurrence of acute myocardial infarction (AMI). We hypothesized that aging may affect the association between the ecNOS gene polymorphism and AMI. METHODS: We investigated the age-related distribution of the ecNOS gene a/b polymorphism in 121 male AMI patients and 206 age-matched healthy male controls. RESULTS: The aa, ab and bb genotypes were found in 1, 49 and 156 cases among the control subjects and 5, 23 and 93 cases among the AMI patients, respectively. There was a significant correlation between the ecNOS polymorphism and AMI (p = 0.045). When the correlation was analyzed by age, the significance remained only in the group below the age of 51 (p = 0.009). The proportion of smokers was increased in the young patients when compared to the old patients (p = 0.033), indicating that smoking also has greater effect on the younger population. The incidences of hypertension and diabetes mellitus, however, were similar in both populations. CONCLUSION: Our work provides the first evidence that links ecNOS polymorphism to the risk of AMI in relation to age. Young persons who smoke or have ecNOSaa genotype may have an increased risk of developing AMI. The functional as well as structural changes associated with aging in the vascular endothelium may mask the effect of the ecNOS polymorphism in the development of AMI in old persons.

Duke Scholars

Published In

Korean J Intern Med

DOI

ISSN

1226-3303

Publication Date

January 2000

Volume

15

Issue

1

Start / End Page

65 / 70

Location

Korea (South)

Related Subject Headings

  • Statistics, Nonparametric
  • Risk Assessment
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Nitric Oxide Synthase
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Korea
  • Hypertension
 

Citation

APA
Chicago
ICMJE
MLA
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Park, J. E., Lee, W. H., Hwang, T. H., Chu, J. A., Kim, S., Choi, Y. H., … Lee, W. R. (2000). Aging affects the association between endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction in the Korean male population. Korean J Intern Med, 15(1), 65–70. https://doi.org/10.3904/kjim.2000.15.1.65
Park, J. E., W. H. Lee, T. H. Hwang, J. A. Chu, S. Kim, Y. H. Choi, J. S. Kim, et al. “Aging affects the association between endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction in the Korean male population.Korean J Intern Med 15, no. 1 (January 2000): 65–70. https://doi.org/10.3904/kjim.2000.15.1.65.
Park JE, Lee WH, Hwang TH, Chu JA, Kim S, Choi YH, et al. Aging affects the association between endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction in the Korean male population. Korean J Intern Med. 2000 Jan;15(1):65–70.
Park, J. E., et al. “Aging affects the association between endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction in the Korean male population.Korean J Intern Med, vol. 15, no. 1, Jan. 2000, pp. 65–70. Pubmed, doi:10.3904/kjim.2000.15.1.65.
Park JE, Lee WH, Hwang TH, Chu JA, Kim S, Choi YH, Kim JS, Kim DK, Lee SH, Hong KP, Seo JD, Lee WR. Aging affects the association between endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction in the Korean male population. Korean J Intern Med. 2000 Jan;15(1):65–70.

Published In

Korean J Intern Med

DOI

ISSN

1226-3303

Publication Date

January 2000

Volume

15

Issue

1

Start / End Page

65 / 70

Location

Korea (South)

Related Subject Headings

  • Statistics, Nonparametric
  • Risk Assessment
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Nitric Oxide Synthase
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Korea
  • Hypertension