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Immunohistochemical examination of an orbital alveolar soft part sarcoma.

Publication ,  Journal Article
Coupland, SE; Heimann, H; Hoffmeister, B; Lee, WR; Foerster, MH; Gross, U
Published in: Graefes Arch Clin Exp Ophthalmol
April 1999

BACKGROUND: A 32 year-old male patient had a 6-week history of left-sided proptosis. Computer tomography revealed a 16x15x15 mm smooth and well-defined mass between the optic nerve and the medial and superior rectus muscles in the left orbit. METHODS: The tumour was excised via a cranio-medial orbitotomy approach. RESULTS: Histopathological examination, immunohistochemistry and electron microscopy findings were consistent with an alveolar soft part sarcoma. Immunohistochemical staining showed positive immunoreactivity for neuronespecific enolase, vimentin, p53 (30%), p21 (10%) and cyclin D1 (20%), and negative immunoreactivity for CD45, cytokeratins, S-100 protein, glial fibrillary acidic protein, synaptophysin, chromogranin, calcitonin, serotonin, thyreoglobulin, desmin, myosin, actin, HMB-45, pRB, p16 and BCL-2. The growth fraction of the tumour cells was 3%. At examination 4 years after surgical excision, there was no evidence of local recurrence or for metastases. CONCLUSION: Alveolar soft part sarcoma of the orbit is a rare malignant tumour best controlled by surgery. The unpredictable behaviour of these neoplasms, however, indicates the need for long-term follow-up.

Duke Scholars

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

April 1999

Volume

237

Issue

4

Start / End Page

266 / 272

Location

Germany

Related Subject Headings

  • Vimentin
  • Tumor Suppressor Protein p53
  • Tomography, X-Ray Computed
  • Sarcoma, Alveolar Soft Part
  • Phosphopyruvate Hydratase
  • Orbital Neoplasms
  • Ophthalmology & Optometry
  • Male
  • Immunoenzyme Techniques
  • Humans
 

Citation

APA
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Coupland, S. E., Heimann, H., Hoffmeister, B., Lee, W. R., Foerster, M. H., & Gross, U. (1999). Immunohistochemical examination of an orbital alveolar soft part sarcoma. Graefes Arch Clin Exp Ophthalmol, 237(4), 266–272. https://doi.org/10.1007/s004170050231
Coupland, S. E., H. Heimann, B. Hoffmeister, W. R. Lee, M. H. Foerster, and U. Gross. “Immunohistochemical examination of an orbital alveolar soft part sarcoma.Graefes Arch Clin Exp Ophthalmol 237, no. 4 (April 1999): 266–72. https://doi.org/10.1007/s004170050231.
Coupland SE, Heimann H, Hoffmeister B, Lee WR, Foerster MH, Gross U. Immunohistochemical examination of an orbital alveolar soft part sarcoma. Graefes Arch Clin Exp Ophthalmol. 1999 Apr;237(4):266–72.
Coupland, S. E., et al. “Immunohistochemical examination of an orbital alveolar soft part sarcoma.Graefes Arch Clin Exp Ophthalmol, vol. 237, no. 4, Apr. 1999, pp. 266–72. Pubmed, doi:10.1007/s004170050231.
Coupland SE, Heimann H, Hoffmeister B, Lee WR, Foerster MH, Gross U. Immunohistochemical examination of an orbital alveolar soft part sarcoma. Graefes Arch Clin Exp Ophthalmol. 1999 Apr;237(4):266–272.
Journal cover image

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

April 1999

Volume

237

Issue

4

Start / End Page

266 / 272

Location

Germany

Related Subject Headings

  • Vimentin
  • Tumor Suppressor Protein p53
  • Tomography, X-Ray Computed
  • Sarcoma, Alveolar Soft Part
  • Phosphopyruvate Hydratase
  • Orbital Neoplasms
  • Ophthalmology & Optometry
  • Male
  • Immunoenzyme Techniques
  • Humans