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Virus-based gene therapy strategies for bone regeneration.

Publication ,  Journal Article
Phillips, JE; Gersbach, CA; García, AJ
Published in: Biomaterials
January 2007

Gene therapy has emerged as a promising strategy for the repair and regeneration of damaged musculoskeletal tissues. Application of this paradigm to bone healing has shown enhanced efficacy in preclinical animal studies compared to conventional bone grafting approaches. This review discusses current and emerging virus-based genetic engineering strategies for the delivery of therapeutic molecules which promote skeletal regeneration. Viral gene delivery vectors are discussed in the context of bone repair in order to illustrate the challenges and applications of these methods with tissue-specific examples. Moreover the concepts discussed can be broadly applied to promote healing in a wide range of tissues. We also present important considerations involved in the application of these gene therapy techniques to a variety of osteogenic (e.g. bone marrow-derived cells) and non-osteogenic (e.g. fibroblasts and skeletal myoblasts) cell types. Criteria for the selection of regenerative molecules with soluble versus intracellular modes of action and emerging combinatorial approaches are also discussed. Overall, gene transfer technologies have the potential to overcome limitations associated with existing bone grafting approaches and may enable investigators to design therapies which more closely mimic the complex spatial and temporal cascade of proteins involved in endogenous bone development and repair.

Duke Scholars

Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

January 2007

Volume

28

Issue

2

Start / End Page

211 / 229

Related Subject Headings

  • Viruses
  • Tissue Engineering
  • Humans
  • Genetic Vectors
  • Genetic Therapy
  • Gene Transfer Techniques
  • Bone Regeneration
  • Bone Diseases
  • Biomedical Engineering
  • Animals
 

Citation

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ICMJE
MLA
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Phillips, J. E., Gersbach, C. A., & García, A. J. (2007). Virus-based gene therapy strategies for bone regeneration. Biomaterials, 28(2), 211–229. https://doi.org/10.1016/j.biomaterials.2006.07.032
Phillips, Jennifer E., Charles A. Gersbach, and Andrés J. García. “Virus-based gene therapy strategies for bone regeneration.Biomaterials 28, no. 2 (January 2007): 211–29. https://doi.org/10.1016/j.biomaterials.2006.07.032.
Phillips JE, Gersbach CA, García AJ. Virus-based gene therapy strategies for bone regeneration. Biomaterials. 2007 Jan;28(2):211–29.
Phillips, Jennifer E., et al. “Virus-based gene therapy strategies for bone regeneration.Biomaterials, vol. 28, no. 2, Jan. 2007, pp. 211–29. Epmc, doi:10.1016/j.biomaterials.2006.07.032.
Phillips JE, Gersbach CA, García AJ. Virus-based gene therapy strategies for bone regeneration. Biomaterials. 2007 Jan;28(2):211–229.
Journal cover image

Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

January 2007

Volume

28

Issue

2

Start / End Page

211 / 229

Related Subject Headings

  • Viruses
  • Tissue Engineering
  • Humans
  • Genetic Vectors
  • Genetic Therapy
  • Gene Transfer Techniques
  • Bone Regeneration
  • Bone Diseases
  • Biomedical Engineering
  • Animals