Skip to main content
Journal cover image

A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.

Publication ,  Journal Article
Tenor, JL; Aballay, A
Published in: EMBO Rep
January 2008

Pathogen recognition through Toll-like receptors (TLRs) is crucial in order to mount an appropriate immune response against microorganisms. On the basis of a lack of evidence indicating that Caenorhabditis elegans uses TLRs to elicit an immune response and on the absence of genes encoding Rel-like transcription factors in its genome, it is believed that TLR-mediated immunity arose after coelomates split from pseudocoelomates and acoelomates. Here, we show that C. elegans tol-1(nr2033) mutants are killed by the human pathogen Salmonella enterica, which causes a significant pharyngeal invasion in the absence of TOL-1-mediated immunity. We also show that TOL-1 is required for the correct expression of ABF-2, which is a defensin-like molecule expressed in the pharynx, and heat-shock protein 16.41, which is also expressed in the pharynx and is part of a HSP family of proteins required for C. elegans immunity. The results indicate that TOL-1 has a direct role in defence response to certain Gram-negative bacteria and indicate that part of the TLR-mediated immunity might be evolutionarily conserved.

Duke Scholars

Published In

EMBO Rep

DOI

ISSN

1469-221X

Publication Date

January 2008

Volume

9

Issue

1

Start / End Page

103 / 109

Location

England

Related Subject Headings

  • Salmonella enterica
  • Pharynx
  • Nerve Tissue Proteins
  • Mutation
  • Immunity, Innate
  • Developmental Biology
  • Conserved Sequence
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tenor, J. L., & Aballay, A. (2008). A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. EMBO Rep, 9(1), 103–109. https://doi.org/10.1038/sj.embor.7401104
Tenor, Jennifer L., and Alejandro Aballay. “A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.EMBO Rep 9, no. 1 (January 2008): 103–9. https://doi.org/10.1038/sj.embor.7401104.
Tenor, Jennifer L., and Alejandro Aballay. “A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.EMBO Rep, vol. 9, no. 1, Jan. 2008, pp. 103–09. Pubmed, doi:10.1038/sj.embor.7401104.
Journal cover image

Published In

EMBO Rep

DOI

ISSN

1469-221X

Publication Date

January 2008

Volume

9

Issue

1

Start / End Page

103 / 109

Location

England

Related Subject Headings

  • Salmonella enterica
  • Pharynx
  • Nerve Tissue Proteins
  • Mutation
  • Immunity, Innate
  • Developmental Biology
  • Conserved Sequence
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Animals