Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage.
Publication
, Journal Article
McCarron, MO; Weir, CJ; Muir, KW; Hoffmann, KL; Graffagnino, C; Nicoll, JAR; Lees, KR; Alberts, MJ
Published in: Acta Neurol Scand
February 2003
OBJECTIVE: To determine the relationship between the apolipoprotein E (APOE) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). MATERIAL AND METHODS: Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. RESULTS: There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOEepsilon4 allele (P = 0.026) significantly reduced in-hospital survival. CONCLUSION: The APOEepsilon4 allele in this population may be associated with poor survival following ICH.
Duke Scholars
Published In
Acta Neurol Scand
DOI
ISSN
0001-6314
Publication Date
February 2003
Volume
107
Issue
2
Start / End Page
106 / 109
Location
Denmark
Related Subject Headings
- United States
- United Kingdom
- Sex Distribution
- Racial Groups
- Prospective Studies
- Neurology & Neurosurgery
- Multivariate Analysis
- Male
- Logistic Models
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
McCarron, M. O., Weir, C. J., Muir, K. W., Hoffmann, K. L., Graffagnino, C., Nicoll, J. A. R., … Alberts, M. J. (2003). Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. Acta Neurol Scand, 107(2), 106–109. https://doi.org/10.1034/j.1600-0404.2003.01365.x
McCarron, M. O., C. J. Weir, K. W. Muir, K. L. Hoffmann, C. Graffagnino, J. A. R. Nicoll, K. R. Lees, and M. J. Alberts. “Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage.” Acta Neurol Scand 107, no. 2 (February 2003): 106–9. https://doi.org/10.1034/j.1600-0404.2003.01365.x.
McCarron MO, Weir CJ, Muir KW, Hoffmann KL, Graffagnino C, Nicoll JAR, et al. Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. Acta Neurol Scand. 2003 Feb;107(2):106–9.
McCarron, M. O., et al. “Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage.” Acta Neurol Scand, vol. 107, no. 2, Feb. 2003, pp. 106–09. Pubmed, doi:10.1034/j.1600-0404.2003.01365.x.
McCarron MO, Weir CJ, Muir KW, Hoffmann KL, Graffagnino C, Nicoll JAR, Lees KR, Alberts MJ. Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. Acta Neurol Scand. 2003 Feb;107(2):106–109.
Published In
Acta Neurol Scand
DOI
ISSN
0001-6314
Publication Date
February 2003
Volume
107
Issue
2
Start / End Page
106 / 109
Location
Denmark
Related Subject Headings
- United States
- United Kingdom
- Sex Distribution
- Racial Groups
- Prospective Studies
- Neurology & Neurosurgery
- Multivariate Analysis
- Male
- Logistic Models
- Humans