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Arterial compliance in adolescents and young adults receiving chronic hemodialysis.

Publication ,  Journal Article
Gbadegesin, R; Kudelka, T; Gadegbeku, CA; Brophy, P; Smoyer, WE; Lin, J-J
Published in: Ren Fail
2008

Increased vascular stiffness is an established risk marker of cardiovascular diseases (CVD) in adults with end-stage renal disease, but its role in pediatric patients remains to be defined. We prospectively examined arterial compliances of adolescents and young adults on hemodialysis (HD) using diastolic pulse wave analysis (DPWA). Each of the ten HD patients (age 17.3 +/- 3.9 years; mean +/- SD) had two DPWA tests within a three-week time period. DPWA measurement was performed before and hourly until the end of three-hour HD. Pre-HD large artery elasticity index (LAEI) was reduced in one patient and small artery elasticity index (SAEI) was reduced in another. Neither patient was hypertensive. Eight other patients had a reduction in both LAEI and SAEI. Among them, six patients had systolic and/or diastolic hypertension, and the other two were normotensive. Serum phosphorus correlated positively with stroke volume and cardiac output indices and negatively with SAEI. The reduction in BP during HD correlated with the amount of fluid removal. LAEI and SAEI were unchanged during HD. In conclusion, the reduction in LAEI and/or SAEI was observed in four normotensive patients, suggesting hypertension was not the only contributing factor for the reduced arterial compliances in our patients. The association between SAEI and serum phosphorus suggests that SAEI derived from DPWA can potentially be an early non-invasive, operator-independent, and volume-independent marker of CVD in adolescents and young adults receiving HD. Longitudinal studies with a larger sample size are needed to confirm our observation and speculation.

Duke Scholars

Published In

Ren Fail

DOI

EISSN

1525-6049

Publication Date

2008

Volume

30

Issue

6

Start / End Page

591 / 596

Location

England

Related Subject Headings

  • Vascular Resistance
  • Urology & Nephrology
  • Treatment Outcome
  • Risk Assessment
  • Renal Dialysis
  • Pulsatile Flow
  • Prospective Studies
  • Probability
  • Male
  • Long-Term Care
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gbadegesin, R., Kudelka, T., Gadegbeku, C. A., Brophy, P., Smoyer, W. E., & Lin, J.-J. (2008). Arterial compliance in adolescents and young adults receiving chronic hemodialysis. Ren Fail, 30(6), 591–596. https://doi.org/10.1080/08860220802132064
Gbadegesin, Rasheed, Timothy Kudelka, Crystal A. Gadegbeku, Patrick Brophy, William E. Smoyer, and Jen-Jar Lin. “Arterial compliance in adolescents and young adults receiving chronic hemodialysis.Ren Fail 30, no. 6 (2008): 591–96. https://doi.org/10.1080/08860220802132064.
Gbadegesin R, Kudelka T, Gadegbeku CA, Brophy P, Smoyer WE, Lin J-J. Arterial compliance in adolescents and young adults receiving chronic hemodialysis. Ren Fail. 2008;30(6):591–6.
Gbadegesin, Rasheed, et al. “Arterial compliance in adolescents and young adults receiving chronic hemodialysis.Ren Fail, vol. 30, no. 6, 2008, pp. 591–96. Pubmed, doi:10.1080/08860220802132064.
Gbadegesin R, Kudelka T, Gadegbeku CA, Brophy P, Smoyer WE, Lin J-J. Arterial compliance in adolescents and young adults receiving chronic hemodialysis. Ren Fail. 2008;30(6):591–596.

Published In

Ren Fail

DOI

EISSN

1525-6049

Publication Date

2008

Volume

30

Issue

6

Start / End Page

591 / 596

Location

England

Related Subject Headings

  • Vascular Resistance
  • Urology & Nephrology
  • Treatment Outcome
  • Risk Assessment
  • Renal Dialysis
  • Pulsatile Flow
  • Prospective Studies
  • Probability
  • Male
  • Long-Term Care