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Searching for genes that matter in acute kidney injury: a systematic review.

Publication ,  Journal Article
Lu, JCT; Coca, SG; Patel, UD; Cantley, L; Parikh, CR ...
Published in: Clin J Am Soc Nephrol
June 2009

BACKGROUND AND OBJECTIVES: Identifying patients who may develop acute kidney injury (AKI) remains challenging, as clinical determinants explain only a portion of individual risk. Another factor that likely affects risk is intrinsic genetic variability. Therefore, a systematic review of studies was performed that related the development or prognosis of AKI to genetic variation. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: MEDLINE, EMBASE, HuGEnet, SCOPUS, and Web of Science were searched for articles from 1950 to Dec 2007. Two independent researchers screened articles using predetermined criteria. Studies were assessed for methodological quality via an aggregate scoring system. RESULTS: The 16 included studies were of cohort or case-cohort design and investigated 35 polymorphisms in 21 genes in association with AKI. Fifteen gene-gene interactions were also investigated in four separate studies. Study populations were primarily premature infants or adults who were critically ill or postcardiac bypass patients. Among the studies, five different definitions of AKI were used. Only one polymorphism, APO E e2/e3/e4, had greater than one study showing a significant impact (P < 0.05) on AKI incidence. The mean quality score of 5.8/10 (range four to nine), heterogeneity in the studies, and the dearth of studies precluded additional meta-analysis of the results. CONCLUSIONS: Current association studies are unable to provide definitive evidence linking genetic variation to AKI. Future success will require a narrow consensus definition of AKI, rigorous epidemiologic techniques, and a shift from a priori hypothesis-driven to genome-wide association studies.

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Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

June 2009

Volume

4

Issue

6

Start / End Page

1020 / 1031

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Polymorphism, Genetic
  • Incidence
  • Humans
  • Genomics
  • Genetic Predisposition to Disease
  • Acute Lung Injury
  • 4202 Epidemiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lu, J. C. T., Coca, S. G., Patel, U. D., Cantley, L., Parikh, C. R., & Translational Research Investigating Biomarkers and Endpoints for Acute Kidney Injury (TRIBE-AKI) Consortium, . (2009). Searching for genes that matter in acute kidney injury: a systematic review. Clin J Am Soc Nephrol, 4(6), 1020–1031. https://doi.org/10.2215/CJN.05411008
Lu, Jonathan C. T., Steven G. Coca, Uptal D. Patel, Lloyd Cantley, Chirag R. Parikh, and Chirag R. Translational Research Investigating Biomarkers and Endpoints for Acute Kidney Injury (TRIBE-AKI) Consortium. “Searching for genes that matter in acute kidney injury: a systematic review.Clin J Am Soc Nephrol 4, no. 6 (June 2009): 1020–31. https://doi.org/10.2215/CJN.05411008.
Lu JCT, Coca SG, Patel UD, Cantley L, Parikh CR, Translational Research Investigating Biomarkers and Endpoints for Acute Kidney Injury (TRIBE-AKI) Consortium. Searching for genes that matter in acute kidney injury: a systematic review. Clin J Am Soc Nephrol. 2009 Jun;4(6):1020–31.
Lu, Jonathan C. T., et al. “Searching for genes that matter in acute kidney injury: a systematic review.Clin J Am Soc Nephrol, vol. 4, no. 6, June 2009, pp. 1020–31. Pubmed, doi:10.2215/CJN.05411008.
Lu JCT, Coca SG, Patel UD, Cantley L, Parikh CR, Translational Research Investigating Biomarkers and Endpoints for Acute Kidney Injury (TRIBE-AKI) Consortium. Searching for genes that matter in acute kidney injury: a systematic review. Clin J Am Soc Nephrol. 2009 Jun;4(6):1020–1031.

Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

June 2009

Volume

4

Issue

6

Start / End Page

1020 / 1031

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Polymorphism, Genetic
  • Incidence
  • Humans
  • Genomics
  • Genetic Predisposition to Disease
  • Acute Lung Injury
  • 4202 Epidemiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences