Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain.
Publication
, Journal Article
Mikati, MA; Zeinieh, MP; Kurdi, RM; Harb, SA; El Hokayem, JA; Daderian, RH; Shamseddine, A; Obeid, M; Bitar, FF; El Sabban, M
Published in: Brain Res Dev Brain Res
June 9, 2005
Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O2) had as adults increased aggression (handling test), memory impairment (water maze test), and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts. Chronic hypoxia with superimposed acute hypoxia resulted in consequences that were not different from those of chronic hypoxia.
Duke Scholars
Published In
Brain Res Dev Brain Res
DOI
ISSN
0165-3806
Publication Date
June 9, 2005
Volume
157
Issue
1
Start / End Page
98 / 102
Location
Netherlands
Related Subject Headings
- Time Factors
- Time
- Rats, Sprague-Dawley
- Rats
- Neurology & Neurosurgery
- Maze Learning
- In Situ Nick-End Labeling
- Hypoxia
- Hippocampus
- Exploratory Behavior
Citation
APA
Chicago
ICMJE
MLA
NLM
Mikati, M. A., Zeinieh, M. P., Kurdi, R. M., Harb, S. A., El Hokayem, J. A., Daderian, R. H., … El Sabban, M. (2005). Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain. Brain Res Dev Brain Res, 157(1), 98–102. https://doi.org/10.1016/j.devbrainres.2005.03.007
Mikati, Mohamad A., Michele P. Zeinieh, Rana M. Kurdi, Samer A. Harb, Jimmy A. El Hokayem, Rita H. Daderian, Alhan Shamseddine, Makram Obeid, Fadi F. Bitar, and Marwan El Sabban. “Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain.” Brain Res Dev Brain Res 157, no. 1 (June 9, 2005): 98–102. https://doi.org/10.1016/j.devbrainres.2005.03.007.
Mikati MA, Zeinieh MP, Kurdi RM, Harb SA, El Hokayem JA, Daderian RH, et al. Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain. Brain Res Dev Brain Res. 2005 Jun 9;157(1):98–102.
Mikati, Mohamad A., et al. “Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain.” Brain Res Dev Brain Res, vol. 157, no. 1, June 2005, pp. 98–102. Pubmed, doi:10.1016/j.devbrainres.2005.03.007.
Mikati MA, Zeinieh MP, Kurdi RM, Harb SA, El Hokayem JA, Daderian RH, Shamseddine A, Obeid M, Bitar FF, El Sabban M. Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain. Brain Res Dev Brain Res. 2005 Jun 9;157(1):98–102.
Published In
Brain Res Dev Brain Res
DOI
ISSN
0165-3806
Publication Date
June 9, 2005
Volume
157
Issue
1
Start / End Page
98 / 102
Location
Netherlands
Related Subject Headings
- Time Factors
- Time
- Rats, Sprague-Dawley
- Rats
- Neurology & Neurosurgery
- Maze Learning
- In Situ Nick-End Labeling
- Hypoxia
- Hippocampus
- Exploratory Behavior