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Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats.

Publication ,  Journal Article
Mikati, MA; Holmes, GL; Werner, S; Bakkar, N; Carmant, L; Liu, Z; Stafstrom, CE
Published in: Epilepsy Behav
April 2004

OBJECTIVE: The goal of this study was to investigate the potential protective effects of nimodipine (ND), a calcium channel blocker, on the acute manifestations and long-term behavioral sequalae of experimental status epilepticus (SE). METHODS: Three groups of Postnatal Day (P) 35 rats undergoing kainic acid (KA)-induced SE were injected with phenobarbital (PB) and/or ND, and were subsequently compared with rats injected with KA alone and normal control rats. Behavioral parameters were assessed by the Morris water maze, open field, and handling tests at P125-P135. Acute seizures and spontaneous recurrent seizures (SRS) were assessed by videotape techniques. RESULTS: PB reduced the severity of SE acutely, and protected completely against subsequent long-term SRS, memory impairment, and hyperactivity, and partially against aggressivity. ND alone had no effect on acute seizure activity, but did protect against subsequent SRS and memory impairment, and partially against aggressivity. When administered together, PB and ND had effects similar to those seen with PB alone. However, in addition, and unlike the PB- and ND-alone groups, the PB-ND group was completely protected against KA-induced increased aggressivity. CONCLUSIONS: Activation of L-type calcium channels contributes to the long-term behavioral sequalae of KA-induced SE, but is not essential for the development and maintenance of SE. ND has protective effects in SE when given alone or in conjunction with a traditional antiepileptic drug. Calcium channel blockers should be further investigated as add-on protective agents in models of SE and possibly in clinical trials.

Duke Scholars

Published In

Epilepsy Behav

DOI

ISSN

1525-5050

Publication Date

April 2004

Volume

5

Issue

2

Start / End Page

168 / 174

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Rats, Sprague-Dawley
  • Rats
  • Premedication
  • Phenobarbital
  • Nimodipine
  • Neurology & Neurosurgery
  • Motor Activity
  • Memory
  • Maze Learning
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mikati, M. A., Holmes, G. L., Werner, S., Bakkar, N., Carmant, L., Liu, Z., & Stafstrom, C. E. (2004). Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats. Epilepsy Behav, 5(2), 168–174. https://doi.org/10.1016/j.yebeh.2003.12.002
Mikati, Mohamad A., Gregory L. Holmes, Suzanne Werner, Nadine Bakkar, Lionel Carmant, Zhao Liu, and Carl E. Stafstrom. “Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats.Epilepsy Behav 5, no. 2 (April 2004): 168–74. https://doi.org/10.1016/j.yebeh.2003.12.002.
Mikati MA, Holmes GL, Werner S, Bakkar N, Carmant L, Liu Z, et al. Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats. Epilepsy Behav. 2004 Apr;5(2):168–74.
Mikati, Mohamad A., et al. “Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats.Epilepsy Behav, vol. 5, no. 2, Apr. 2004, pp. 168–74. Pubmed, doi:10.1016/j.yebeh.2003.12.002.
Mikati MA, Holmes GL, Werner S, Bakkar N, Carmant L, Liu Z, Stafstrom CE. Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats. Epilepsy Behav. 2004 Apr;5(2):168–174.
Journal cover image

Published In

Epilepsy Behav

DOI

ISSN

1525-5050

Publication Date

April 2004

Volume

5

Issue

2

Start / End Page

168 / 174

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Rats, Sprague-Dawley
  • Rats
  • Premedication
  • Phenobarbital
  • Nimodipine
  • Neurology & Neurosurgery
  • Motor Activity
  • Memory
  • Maze Learning