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Comparison of valproate and phenobarbital treatment after status epilepticus in rats.

Publication ,  Journal Article
Bolanos, AR; Sarkisian, M; Yang, Y; Hori, A; Helmers, SL; Mikati, M; Tandon, P; Stafstrom, CE; Holmes, GL
Published in: Neurology
July 1998

OBJECTIVE: To investigate the long-term effects of two widely used antiepileptic medications, valproate and phenobarbital, on learning and behavior in the kainic acid (KA) model of epilepsy. BACKGROUND: Prior clinical and animal studies have demonstrated that phenobarbital administered during development may result in subsequent cognitive impairment. It is unclear whether these adverse effects of phenobarbital extend to other antiepileptic drugs. METHODS: A convulsant dose of KA was administered to rats on postnatal day (P) 35. From P36-75 rats received daily injections of phenobarbital (PH), valproate (VPA), or saline and spontaneous seizure frequency was monitored with video recordings. After tapering of the drugs, the rats were tested in the water maze (a measure of visuospatial memory) and handling test (a measure of emotionality). Brains were then analyzed for histologic lesions. RESULTS: KA caused status epilepticus in all the rats. In the PH- and saline-treated groups, there was impaired learning in the water maze, increased emotionality, recurrent seizures, and histologic lesions in the hippocampal areas CA3, CA1, and dentate hilus. However, VPA-treated rats had no spontaneous seizures, abnormalities in handling, or deficits in visuospatial learning, and had fewer histologic lesions than animals receiving KA alone. CONCLUSIONS: The long-term consequences of AED treatment during development are related to the drug used. VPA treatment after KA-induced status epilepticus prevents many of the neurologic sequelae typically seen after KA.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

July 1998

Volume

51

Issue

1

Start / End Page

41 / 48

Location

United States

Related Subject Headings

  • Valproic Acid
  • Stress, Physiological
  • Status Epilepticus
  • Rats, Sprague-Dawley
  • Rats
  • Phenobarbital
  • Neurology & Neurosurgery
  • Maze Learning
  • Male
  • Kainic Acid
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bolanos, A. R., Sarkisian, M., Yang, Y., Hori, A., Helmers, S. L., Mikati, M., … Holmes, G. L. (1998). Comparison of valproate and phenobarbital treatment after status epilepticus in rats. Neurology, 51(1), 41–48. https://doi.org/10.1212/wnl.51.1.41
Bolanos, A. R., M. Sarkisian, Y. Yang, A. Hori, S. L. Helmers, M. Mikati, P. Tandon, C. E. Stafstrom, and G. L. Holmes. “Comparison of valproate and phenobarbital treatment after status epilepticus in rats.Neurology 51, no. 1 (July 1998): 41–48. https://doi.org/10.1212/wnl.51.1.41.
Bolanos AR, Sarkisian M, Yang Y, Hori A, Helmers SL, Mikati M, et al. Comparison of valproate and phenobarbital treatment after status epilepticus in rats. Neurology. 1998 Jul;51(1):41–8.
Bolanos, A. R., et al. “Comparison of valproate and phenobarbital treatment after status epilepticus in rats.Neurology, vol. 51, no. 1, July 1998, pp. 41–48. Pubmed, doi:10.1212/wnl.51.1.41.
Bolanos AR, Sarkisian M, Yang Y, Hori A, Helmers SL, Mikati M, Tandon P, Stafstrom CE, Holmes GL. Comparison of valproate and phenobarbital treatment after status epilepticus in rats. Neurology. 1998 Jul;51(1):41–48.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

July 1998

Volume

51

Issue

1

Start / End Page

41 / 48

Location

United States

Related Subject Headings

  • Valproic Acid
  • Stress, Physiological
  • Status Epilepticus
  • Rats, Sprague-Dawley
  • Rats
  • Phenobarbital
  • Neurology & Neurosurgery
  • Maze Learning
  • Male
  • Kainic Acid