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Fabrication of Elastin-Like polypeptide Nanoparticles for Drug Delivery by Electrospraying

Publication ,  Journal Article
Wu, YQ; Mackay, JA; Mcdaniel, JR; Chilkoti, A; Clark, RL
Published in: Biomacromolecules
January 2009

The development of environmentally responsive drug carriers requires new methods for assembling stimuli-responsive nanoparticulates. This communication describes a novel application of electrospray to construct bioresponsive peptide-based particulates, which can encapsulate drugs. These particles are composed from genetically engineered elastin-like polypeptides (ELPs), a biodegradable, biocompatible, and bioresponsive polymer. To generate nanoparticles (300-400 nm in diameter), ELPs and drugs are codissolved in organic solvent, accelerated across a voltage gradient, dried by evaporation during transit, and collected from a target surface. These findings indicate that particle diameter, polydispersity, and morphology are strong functions of the solvent concentration, spraying voltage, and polymer molecular weight. Surprisingly, the loading of drug at 20 w/w\% did not influence particle morphology; furthermore, drug release from these particles correlated with the pH-dependent solubility of the parent ELPs. These studies suggest that electrospray is an efficient and flexible method for generating stimuli-responsive drug particles.

Duke Scholars

Published In

Biomacromolecules

ISSN

1525-7797

Publication Date

January 2009

Volume

10

Issue

1

Start / End Page

19 / 24

Related Subject Headings

  • Surface Properties
  • Solubility
  • Polymers
  • Peptides
  • Particle Size
  • Nanoparticles
  • Hydrogen-Ion Concentration
  • Electrochemistry
  • Elastin
  • Drug Delivery Systems
 

Citation

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Wu, Y. Q., Mackay, J. A., Mcdaniel, J. R., Chilkoti, A., & Clark, R. L. (2009). Fabrication of Elastin-Like polypeptide Nanoparticles for Drug Delivery by Electrospraying. Biomacromolecules, 10(1), 19–24.
Wu, Y. Q., J. A. Mackay, J. R. Mcdaniel, A. Chilkoti, and R. L. Clark. “Fabrication of Elastin-Like polypeptide Nanoparticles for Drug Delivery by Electrospraying.” Biomacromolecules 10, no. 1 (January 2009): 19–24.
Wu YQ, Mackay JA, Mcdaniel JR, Chilkoti A, Clark RL. Fabrication of Elastin-Like polypeptide Nanoparticles for Drug Delivery by Electrospraying. Biomacromolecules. 2009 Jan;10(1):19–24.
Wu, Y. Q., et al. “Fabrication of Elastin-Like polypeptide Nanoparticles for Drug Delivery by Electrospraying.” Biomacromolecules, vol. 10, no. 1, Jan. 2009, pp. 19–24.
Wu YQ, Mackay JA, Mcdaniel JR, Chilkoti A, Clark RL. Fabrication of Elastin-Like polypeptide Nanoparticles for Drug Delivery by Electrospraying. Biomacromolecules. 2009 Jan;10(1):19–24.
Journal cover image

Published In

Biomacromolecules

ISSN

1525-7797

Publication Date

January 2009

Volume

10

Issue

1

Start / End Page

19 / 24

Related Subject Headings

  • Surface Properties
  • Solubility
  • Polymers
  • Peptides
  • Particle Size
  • Nanoparticles
  • Hydrogen-Ion Concentration
  • Electrochemistry
  • Elastin
  • Drug Delivery Systems