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Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology.

Publication ,  Journal Article
Chilkoti, A; Christensen, T; MacKay, JA
Published in: Current opinion in chemical biology
December 2006

Elastin-like polypeptides (ELPs) are artificial polypeptides, derived from Val-Pro-Gly-Xaa-Gly (VPGXG) pentapeptide repeats found in human tropoelastin, that reversibly coacervate above a critical temperature. Genetically encodable ELPs are monodisperse, stimuli responsive, and biocompatible, properties that make them attractive for drug delivery and tissue engineering. The potential of ELPs to self-assemble into nanostructures in response to environmental triggers is another interesting feature of these polypeptides that promises to lead to a host of new applications.

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Published In

Current opinion in chemical biology

DOI

EISSN

1879-0402

ISSN

1367-5931

Publication Date

December 2006

Volume

10

Issue

6

Start / End Page

652 / 657

Related Subject Headings

  • Tissue Engineering
  • Recombinant Fusion Proteins
  • Organic Chemistry
  • Elastin
  • Biotechnology
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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Chilkoti, A., Christensen, T., & MacKay, J. A. (2006). Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology. Current Opinion in Chemical Biology, 10(6), 652–657. https://doi.org/10.1016/j.cbpa.2006.10.010
Chilkoti, Ashutosh, Trine Christensen, and J Andrew MacKay. “Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology.Current Opinion in Chemical Biology 10, no. 6 (December 2006): 652–57. https://doi.org/10.1016/j.cbpa.2006.10.010.
Chilkoti A, Christensen T, MacKay JA. Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology. Current opinion in chemical biology. 2006 Dec;10(6):652–7.
Chilkoti, Ashutosh, et al. “Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology.Current Opinion in Chemical Biology, vol. 10, no. 6, Dec. 2006, pp. 652–57. Epmc, doi:10.1016/j.cbpa.2006.10.010.
Chilkoti A, Christensen T, MacKay JA. Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology. Current opinion in chemical biology. 2006 Dec;10(6):652–657.
Journal cover image

Published In

Current opinion in chemical biology

DOI

EISSN

1879-0402

ISSN

1367-5931

Publication Date

December 2006

Volume

10

Issue

6

Start / End Page

652 / 657

Related Subject Headings

  • Tissue Engineering
  • Recombinant Fusion Proteins
  • Organic Chemistry
  • Elastin
  • Biotechnology
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry