Skip to main content
Journal cover image

Protein-resistant polymer coatings on silicon oxide by surface-initiated atom transfer radical polymerization.

Publication ,  Journal Article
Ma, H; Li, D; Sheng, X; Zhao, B; Chilkoti, A
Published in: Langmuir : the ACS journal of surfaces and colloids
April 2006

The modification of silicon oxide with poly(ethylene glycol) to effectively eliminate protein adsorption has proven to be technically challenging. In this paper, we demonstrate that surface-initiated atom transfer radical polymerization (SI-ATRP) of oligo(ethylene glycol) methyl methacrylate (OEGMA) successfully produces polymer coatings on silicon oxide that have excellent protein resistance in a biological milieu. The level of serum adsorption on these coatings is below the detection limit of ellipsometry. We also demonstrate a new soft lithography method via which SI-ATRP is integrated with microcontact printing to create micropatterns of poly(OEGMA) on glass that can spatially direct the adsorption of proteins on the bare regions of the substrate. This ensemble of methods will be useful in screening biological interactions where nonspecific binding must be suppressed to discern low probability binding events from a complex mixture and to pattern anchorage-dependent cells on glass and silicon oxide.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

April 2006

Volume

22

Issue

8

Start / End Page

3751 / 3756

Related Subject Headings

  • Surface Properties
  • Spectrometry, X-Ray Emission
  • Silicon Dioxide
  • Silicon Compounds
  • Silicon
  • Silanes
  • Polymers
  • Polyethylene Glycols
  • Oxides
  • Models, Chemical
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ma, H., Li, D., Sheng, X., Zhao, B., & Chilkoti, A. (2006). Protein-resistant polymer coatings on silicon oxide by surface-initiated atom transfer radical polymerization. Langmuir : The ACS Journal of Surfaces and Colloids, 22(8), 3751–3756. https://doi.org/10.1021/la052796r
Ma, Hongwei, Dejin Li, Xia Sheng, Bin Zhao, and Ashutosh Chilkoti. “Protein-resistant polymer coatings on silicon oxide by surface-initiated atom transfer radical polymerization.Langmuir : The ACS Journal of Surfaces and Colloids 22, no. 8 (April 2006): 3751–56. https://doi.org/10.1021/la052796r.
Ma H, Li D, Sheng X, Zhao B, Chilkoti A. Protein-resistant polymer coatings on silicon oxide by surface-initiated atom transfer radical polymerization. Langmuir : the ACS journal of surfaces and colloids. 2006 Apr;22(8):3751–6.
Ma, Hongwei, et al. “Protein-resistant polymer coatings on silicon oxide by surface-initiated atom transfer radical polymerization.Langmuir : The ACS Journal of Surfaces and Colloids, vol. 22, no. 8, Apr. 2006, pp. 3751–56. Epmc, doi:10.1021/la052796r.
Ma H, Li D, Sheng X, Zhao B, Chilkoti A. Protein-resistant polymer coatings on silicon oxide by surface-initiated atom transfer radical polymerization. Langmuir : the ACS journal of surfaces and colloids. 2006 Apr;22(8):3751–3756.
Journal cover image

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

April 2006

Volume

22

Issue

8

Start / End Page

3751 / 3756

Related Subject Headings

  • Surface Properties
  • Spectrometry, X-Ray Emission
  • Silicon Dioxide
  • Silicon Compounds
  • Silicon
  • Silanes
  • Polymers
  • Polyethylene Glycols
  • Oxides
  • Models, Chemical